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G protein-coupled receptors (GPCRs) are among the most promising drug targets. dimers with ligands is a good approach to clarify their physiological roles and validate them as drug targets

Therapeutic, Inc. a pre-clinical stage biotechnology company transforming the discovery of novel GPCR-targeted

Therefore, the ascaroside signaling system provides a unique example of a signaling molecule that regulates C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions

biomedical sciences with the mechanistic understanding of one of the biggest classes of pharmaceutical targets

enables cholesterol-dependent activation of the master growth regulator, the protein kinase mechanistic target

stage international biopharmaceutical company with an innovative approach to drug discovery based on targeting

Therapeutics, a biopharmaceutical company specializing in the research and development of innovative drugs targeting

adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target

Accordingly, from the information provided, it is plausible that specific PLC isozymes could be targeted

elucidating the metabolic pathways involved in metabolic dysfunction and in developing new drugs as specific targets

PKA facilitates the actions of hormones, neurotransmitters and other signaling molecules that bind G-protein

Finally, we briefly discuss the therapeutic targeting of vGPCRs as future treatment of acute and chronic

August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide

One potential solution is to develop analgesics that act at targets other than opioid receptors.

August 2022 "Despite the importance of members of the GPCR superfamily as targets of a broad range of

functions using unique tools, and thus establishes a foundation for the development of fine-tuned aGPCR-targeted

Dipraglurant selectively targets the metabotropic glutamate receptor subtype 5 (mGlu5) through allosteric

critical to the overall biased response observed at CXCR3, which has important implications for drugs targeting

cardiovascular medicine due to the critical physiological roles of these receptors and their prominence as drug targets

However, many new targets, such as Mas-related GPCRs and unexpected new pathways need to be also explored

inflammation is a hallmark of refractory chronic rhinosinusitis (CRS) and considered a major therapeutic target

homeostasis of the ocular surface, alterations in disease settings, and the possible therapeutic potential of targeting

phosphorylation sites are required for recruitment of the adaptor protein STAM1 (signal-transducing adaptor molecule

The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding

is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic target

parameters of serotonin1A receptors in normal cells are consistent with models describing the diffusion of molecules

signaling hubs in cell membranes that regulate a wide range of physiological processes and are popular drug targets

sets the groundwork for the creation of novel D. vitifoliae management strategies that specifically target