receptor 1 (S1PR1) also carry tyrosine sulfation sites in their N-termini that mediate ligand binding and signaling Removal of the terminal sialic acid was also shown to negatively impact signaling as previously appreciated Interestingly, expression of PolySia was able to partially rescue the signaling upon reduction of sulfation

compounds with the highest affinities were demonstrated to be negative allosteric modulators of mGlu5 signaling

mouse PTH1Rs are 91% identical to the human PTH1R) can lead to differences in receptor-binding and signaling

upregulated upon orthodontic compression and inhibits osteoclast differentiation, likely by Rap1a/ERK signaling pathway.

allosteric cross-talk between receptor entities, which contributes to fine-tuning of transmembrane signaling

September 2022 "Heterotrimeric G-protein transducin, Gt, is a key signal transducer and amplifier in

The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated

, and physical properties might impact ligand binding, receptor activation, G protein interactions, signaling dynamics, and signal termination, highlighting the importance of studying their role in the activation

revealed differences between the receptors both in the intracellular regions that regulate the downstream signaling

trafficking of immune cells both towards and within the CNS and it appears that chemokine/chemokine receptor signaling

GPCR Activation and Signaling G protein activation via chemokine (C-X-C motif) receptor 4 and α1b -adrenoceptor

In particular, we identify unique allosteric signal transmission mechanisms between the Nb80-binding

processing, the numerous mediators and receptors involved has led to a large variety of possible therapeutic pathways However, many new targets, such as Mas-related GPCRs and unexpected new pathways need to be also explored

Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways role of ADGRA1 in anxiety control and synaptic function by regulating the PI3K/AKT/GSK-3β and MEK/ERK pathways

primary human hepatocytes; RB1: RB transcriptional corepressor 1; SQSTM1/p62: sequestosome 1; STAT: signal

the mechanism by which MRAP2 regulates G protein-coupled receptors helps in elucidating the metabolic pathways

A detailed analysis of the engagements allows us to design mutations that specifically enhance one pathway

The CCL2/CCR2 pathway plays an important role in oncology, inflammatory, metabolic, and neurological

September 2022 "Activation of the complement pathway results in the production of bioactive C3a, a product

superfamily, and its ligand fractalkine constitute an important biochemical axis that influence many cellular pathways

Molecular determinants of ligand efficacy and potency in GPCR signaling.

residues (W274, D95, V267, L139, V263, M142, T260, R146, R258 and others) involving in the activation pathway

G-protein-coupled receptor (GPCR) proteins are particularly interesting since they are involved in numerous pathways

This study reports robust bidirectional interactions between these two converging receptor pathways.

NF-α1/CPE uniquely interacts with serotonin receptor 5-HTR1E to activate the β-arrestin/ERK/CREB/BCL2 pathway

also helps in combination therapy strategies, where drugs are designed to target multiple sites or pathways

., Sigal, I. S., Caron, M. G., Lefkowitz, R. J., & Strader, C. D. (1986).