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355 items found for "Ya-Tzu Li"
- Inversago Pharma appoints Glenn S. Vraniak as Chief Financial Officer
Vraniak’s career spans more than 20 years of financial and commercial experience in the life sciences
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
involving the gut-brain axis, will gain unique and valuable access to the Sosei Heptares compound library
- Domain Therapeutics Raises $42m Series A Financing
announced today the closing of a US $42m (€39m) series A financing round co-led by Panacea Venture, CTI Life
- Targeting the M1 muscarinic receptor in neurodegenerative disease
cognitive and neurodegenerative disorders and the potential therapeutic benefit of muscarinic M1 selective ligands
- Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders with ...
explored for treating central nervous system and neurologic disorders, particularly movement disorders like
- Sosei Heptares Confirms Senior Leadership Changes to Drive the Company Through the Next Stage ...
structure-based drug design platform and enhancing translational medicine capabilities • ‘Venture-like value generation • Mid-term global expansion plans include drug discovery technology investments, licensing
- Design Pharmaceuticals Closes $5 Million Pre-series A Round to Accelerate Commercialization of ...
Design Pharmaceuticals ’ platform is based on ultrahigh-throughput technologies that biomine drug-like
- Mark Schmeizl - Dr. GPCR Podcast
He is a pro at Matchmaking the top talent in the life sciences with the industry’s leading companies. Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast
- ShouTi Pharma has a brand new website
experienced, innovative, global team on a bold mission to improve health by creating and developing life-changing
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
Currently, there is no cure for RP, and the therapeutic options are limited.
- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
and synthetically initiate robust [Ca2+]i transients and oscillatory [Ca2+]i signaling in chondrocyte-like receptor (GPCR)-mediated [Ca2+]i signaling involvement in chondroprogenitor proliferation and cartilage-like
- G-protein-coupled receptors as therapeutic targets for glioblastoma
Despite this, the prognosis remains poor, with an impacted quality of life during treatment coupled with
- Precise druggability of the PTH type 1 receptor
because their large orthosteric peptide-binding pocket embedded deep within the transmembrane domain limits the identification and development of nonpeptide small molecule ligands.
- Phospholipid Scrambling by G Protein-Coupled Receptors
phospholipids across the two leaflets of biological membranes is crucial for many aspects of cellular life The transport proteins that facilitate this process are classified as pump-like flippases and floppases and channel-like scramblases. In liposomes, opsin scrambles lipids at a unitary rate of >100,000 per second. This groove enables transbilayer lipid movement, conceptualized as the swiping of a credit card (lipid
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
immunohistochemistry; JAK1: Janus kinase 1; LOX: lysyl oxidase; MAP1LC3B/LC3: microtubule associated protein 1 light
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
revealed that postsynaptic cAMP signaling is required for continuous replacement of synapses throughout life
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated This communication involves the ligand-mediated control of cell surface receptors that then direct their The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control A greater understanding of this function of GPCRs is likely to significantly augment our ability to further
- The sixth transmembrane region of a pheromone G-protein coupled receptor, Map3, is implicated in ...
Although such pheromone/receptor systems are likely to function in both mate choice and prezygotic isolation
- Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation
using a chemogenetic approach, the functional role of the astrocytic Gi pathway is not clear, as the literature Gi -DREADD was expressed in hippocampal astrocytes of a lipopolysaccharide (LPS)-induced neuroinflammation
- Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
The conformation-selective antibody, Fab30, promotes partially activated βarr into the activated-like
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Several members of MRGPRs are also expressed in mast cells, macrophages, and in cardiovascular tissue, linking Additionally, we investigated the constitutive (ligand-independent) and basal activity of MRGPRD and
- G protein-coupled receptor interactions and modification of signalling involving the ghrelin ...
GHSR1a now extend to regulation of neurogenesis, learning and memory, gastrointestinal motility, glucose/lipid
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
Taken together, these data demonstrate that key features of the MCMV lifecycle are coordinated in diverse The signalling repertoire of M33 is distinct from cellular GPCRs and little is known of the relevance
- In vivo metabolic effects after acute activation of skeletal muscle G s signaling
However, acute in vivo stimulation of endogenous Gs-coupled receptors enriched in SKM has only a limited impact on whole-body glucose homeostasis, most likely due to the fact that these receptors are also
- Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...
However, intracellular partners linking GPCRs to TASK1 modulation are not yet well-known. Furthermore, ROCK activity assays were performed to evaluate the ability of various physiological GPCR ligands
- HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...
We identify nanobodies that stimulated lipid kinase activity, block Ras activation, and specifically
- Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...
appropriate glucose homeostasis through their secretion of insulin, and islet function can be modified by ligands We have also considered the likely outcomes on islet function that the altered GPCR expression status
- Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial ...
MI was introduced to rats by permanent left anterior descending coronary artery (LAD) ligation.