Search Results
397 items found for "proteomics"
- Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future
October 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable,
- Developing the Cannabinoid Receptor 2 (CB2) pharmacopeia: past, present, and future
August 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though
- Posttranslational modifications in GPCR internalization
August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
Immunohistochemistry, western blot and quantitative real-time PCR techniques were used to analyze β2-AR protein
- Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
trisphosphate, which are downstream signal transducers for the expression of fetal genes, increased protein
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
We also take into account the detrimental effect of mutations carried by distinct signalling proteins
- Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and modulates site and the extracellular domains in conformations modulated by a full agonist, BI167107, and a G-protein-biased
- Adenosine receptor signalling in Alzheimer's disease
Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets
- Adenosine receptor signalling in Alzheimer's disease
Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets
- GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
Although some G-protein coupled receptors (GPCRs) were reported to play roles in osteoblast function,
- TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...
The G protein and intracellular Ca2+ were detected, respectively, by qPCR and Fluo-4AM Ca2+ fluorescent
- Domain Therapeutics and Explicyte enter partnership agreement in immuno-oncology
a biopharmaceutical company specializing in the discovery and development of new drugs targeting G Protein-Coupled
- Endogenous ligand recognition and structural transition of a human PTH receptor
PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R) and activate the stimulatory G-protein
- Discovery and In Vivo Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine..
Chemokine Receptor CXCR3 for Autoimmune Diseases "The chemokine receptor CXCR3 is a seven-transmembrane G-protein-coupled
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
Numerous intracellular mediators are activated by these G protein-coupled receptors based on several
- VIB spin-off Confo Therapeutics Enters Collaborative Agreement with Regeneron
platform, which uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
Numerous intracellular mediators are activated by these G protein-coupled receptors based on several
- Multifunctional role of GPCR signaling in epithelial tube formation
Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface.
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
remains unknown, and there is no ideal drug for the specific treatment of pSS. β-arrestin2 is a key protein that mediates desensitization and internalization of G protein-coupled receptors (GPCRs) and it participates
- Multifunctional role of GPCR signaling in epithelial tube formation
Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface.
- Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
September 2022 "Given the promising clinical value of allosteric modulators of G protein-coupled-receptors
- Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a GPCR
September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid
- Endogenous ligand recognition and structural transition of a human PTH receptor
PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R) and activate the stimulatory G-protein
- Orion Shares New Data on its Latest Best-in-Class Drug Candidate
Biotechnology Canada Ltd, a drug discovery and development company unlocking the therapeutic potential of G Protein-Coupled
- 📰 GPCR Weekly News, April 1 to 7, 2024
through the μ opioid receptor GPCR Binders, Drugs, and more Predicting associations between drugs and G protein-coupled Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein
- Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
CB1 Receptor Bound to a Negative Allosteric Modulator, ORG27569, and Analogs "A growing number of G-protein-coupled
- The Gluopsins: Opsins without the Retinal Binding Lysine
They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a lysine
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors