Ep 57 of the Dr. GPCR podcast is now available! Our guest is Dr. Peter Banks, Scientific Director at BioTek Instruments! Learn about his career today! Listen where you get your podcasts. https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #podcast

., today announced it closed an oversubscribed $33 million financing round, extending its $100 million Therapeutics has completed dosing in a single ascending dose (SAD) Phase 1 study of its lead type 2 Read more at the source #DrGPCR #GPCR #IndustryNews

Hello readers! Check out our GPCR coverage for this week. The workshop includes: 4x 2 hours live Zoom sessions (45-50 minutes lecture + 1-hour Q&A) Thirty minutes μ-opioid receptor Computational modelling of dynamic cAMP responses to GPCR agonists for exploration May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2

In this newly created role, she will focus on the application of artificial intelligence (AI), machine She will maintain both of these roles, in addition to her role at Exscientia . Council at UK Research and Innovation (UKRI). She has played an active role during the COVID-19 pandemic as the UKRI’s COVID Response Director, and R ead more at the source #DrGPCR #GPCR #IndustryNews

receptor GPR84 Drs. receptor gene RpGPCR41 is involved in the resistance of Rhopalosiphum padi to pyrethroids Discovering energy landscapes Structural and Computational Insights into Dynamics and Intermediate States of Orexin 2 May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 FENS Forum 2024 July 8 - 10, 2024 | 4th IRN i-GPCRnet Annual October 2024 | Biologics US 2024 October 2

Update "Company has completed the Phase 1 Clinical Trial for its INV-202 molecule Encouraging Phase 1 results and supportive preclinical package assist in the launch of Phase 2 clinical development Metabolic disorders Favorable safety, tolerability and pharmacokinetic results from the trial warrant further investigation Read more at the source #DrGPCR #GPCR #IndustryNews

Register now and level up your expertise! peptides L-ATRP and D2-ATRP diastereomers activate an endogenous receptor and suppress heart rate in -2 with neuroprotective and neurogenic properties GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Methods & Updates in GPCR Research Probing PAC1 receptor activation across - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics US 2024   October 2

., and Head of UK R&D Tokyo, Japan and Cambridge, UK, 24 March 2022 – Sosei Group Corporation (“the Read more at the source #DrGPCR #GPCR #IndustryNews

induced by a chemerin-derived agonist Functional profiling of the G protein-coupled receptor C3aR1 reveals GPCRs in Neuroscience Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours of the impact of different detergents and nanodiscs on the A2A adenosine receptor Reviews, GPCRs, and May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2

Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor. GPCR Binders, Drugs, and more Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina by Regulating Ca2+ Flux. (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Vice President

Among the different families of G-protein-coupled receptors (GPCRs), adhesion GPCRs (aGPCRs) represent These crystal structures showed how the Stalk region, which is a short peptide released from the GAIN a very interesting area of research. Embo j, 2012. 31(6): p. 1364-78. 2. Qian, Y., Ma, Z., Liu, C., Li, X., Zhu, X., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H.,

established AI framework which involves three stages: 1) feature extraction or pattern identification; 2) crystallography, cryoEM or molecular dynamics simulation experiments). 2. a cellular response (pEC50 or pIC50, respectively), and how long the ligand remains bound to the receptor this field: 1) the quality and availability of data can be a challenge in AI-driven drug discovery; 2) accessibility of databases to a wider audience will encourage the development of new ideas and methods. 2.

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice. Reviews, GPCRs, and more Olfactory Receptors as an Emerging Chemical Sensing Scaffold. Structural and Molecular Insights into GPCR Function The role of G protein conformation in receptor-G (July 2 - 7, 2023).

on Time-resolved cryo-EM of G-protein activation by a GPCR Remi Janicot, Alex Luebbers, Mikel Garcia-Marcos Interested in showcasing your research? region in Gαi proteins: Relevant or not? May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2

The study reports that human white blood cells express an average of 160 GPCR mRNAs, ranging from 123 stem cells, suggesting a potential role in regulating red blood cell production and offering a novel for future research. therapeutic strategies for a range of immune-related conditions. For further details, refer to the full article: DOI: 10.1038/s41597-024-03880-2

Hi readers! Check out our GPCR coverage for this week. Scaling up Functional Analyses of the G Protein-Coupled Receptor Rhodopsin Reviews, GPCRs, and more into GPCR Function GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2

Hello Readers👋, Welcome to our GPCR weekly newsletter! Get ready to stay up-to-date with the latest research, advancements, and news in the field. receptors may contribute to autism. (March 2, 2023) GEM2023. (March 14-17, 2023). SLAS 2023 B Building Biology in 3D Symposium. (July 2 - 7, 2023).

Sodium is a negative allosteric regulator of the ghrelin receptor. injury and repair. Reviews, GPCRs, and more Heterotrimeric G proteins regulate planarian regeneration and behavior. Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs. (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Convergent Research

September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization We demonstrate by pharmacologic inhibition of GRK2/3-mediated phosphorylation of the chemokine receptor that distal, not proximal, C-tail phosphorylation sites are required for recruitment of the adaptor kinase 1/2 phosphorylation. Read more at the source #DrGPCR #GPCR #IndustryNews

their receptors. Their expression profiles at the probe and feeding stages reflected potential regulatory roles in probe By comparison, we found that the Releasing Hormone-Related Peptides (GnRHs) system of Sternorrhyncha was differentiated from those of the other 2 suborders in Hemiptera. Independent secondary losses of the adipokinetic hormone/corazonin-related peptide receptor (ACP) and

Evaluating Valbenazine for Chorea Associated with Huntington Disease " Highly Statistically Significant Reduction in Chorea Movements (p < 0.0001) as Measured by the Unified Huntington's Disease Rating Scale (UHDRS evaluating the efficacy, safety and tolerability of valbenazine, a selective vesicular monoamine transporter 2 The study met the primary endpoint of reduction in severity of chorea, the cardinal motor feature in " Read more at the source #DrGPCR #GPCR #IndustryNews

Hello Readers👋, Thank you for being here with us this week. 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Structural basis of peptide recognition and activation of endothelin receptors. Industry News Professor Dame Carol Robinson Received 2023 ASMS John.B.Fenn Award Exscientia Announces (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs CADD and Informatics

Reviews, GPCRs, and more Recent Studies on Serotonin 5-HT2A Receptor Antagonists in Medicinal Chemistry Mechanism of Activation of the Visual Receptor Rhodopsin. Addex Announces ADX71149 Phase 2 Epilepsy Clinical Study’s Independent Interim Review Committee Recommends received two proof of concept grants from European Research Council (ERC) Addex Reports Q1 2023 Financial (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Vice President

Alix Rouault as our special guest. Subscribe now! DLL4 Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry July 12 - 17 Associate I, Tissue Culture Post-Doc Research Associate Postdoctoral Fellow Explore Dr.

10, 2022 – Confo Therapeutics , a leader in the discovery of medicines targeting G-protein coupled receptors first-in-human trial of their clinical candidate CFTX-1554, a novel inhibitor of the angiotensin II type 2 receptor (AT2R). the safety, tolerability and pharmacokinetics of CFTX-1554 in healthy subjects (NCT05260658). " Read

news related to GPCRs!   -3 receptor (RXFP3) activation in the rat retrosplenial cortex Sarah Bernhard , Drs. -3 receptor (RXFP3) activation in the rat retrosplenial cortex Unveiling the therapeutic prospects of ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus Methods & Updates in GPCR - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics US 2024   October 2

Greetings, avid readers! agonists at the cannabinoid CB1 receptor Why classical receptor theory, which ignores allostery, can Endocrinology, and Taste The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2

Rockman for their review G Protein-Coupled Receptors: A Century of Research and Discovery Dr. Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions GPCRs in Neuroscience cells for nematode hunting Role and recent progress of P2Y12 receptor in cancer development Mutation Reviews, GPCRs, and more Proteome-wide analysis reveals G protein-coupled receptor-like proteins in Webinar - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics US 2024 October 2