Search Results

signaling hubs in cell membranes that regulate a wide range of physiological processes and are popular drug targets

of PxOctβ3 in P. xylostella, thus, providing a theoretical basis for the design of pesticides that target

innate immune cells and intestinal inflammation, and suggest that GPR84 may serve as a potential drug target

autophagy and the CDKN1B-CDK2-CCNE1-E2F1 axis and indicate that ARRB1 may be a potential therapeutic target microtubule associated protein 1 light chain 3 beta; MKI67: marker of proliferation Ki-67; MTOR: mechanistic target

development — Ghent, Belgium – March 10, 2022 – Confo Therapeutics, a leader in the discovery of medicines targeting

It is a therapeutic target because it plays a role in thermogenesis, lipolysis, and bladder relaxation

"Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets

regulation G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the targets

responses to injected PTH analog peptides that are consistent with a fully functional human PTH1R in target

studies "G protein-coupled receptors (GPCRs) are an important receptor superfamily and common therapeutic targets

Our results suggest that strategies to selectively target OGR1 expression may represent a novel therapeutic

glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic target

essential in biology and understanding how cells integrate signals from a variety of information-coding molecules

discovery and optimization platform of Twist Biopharma to license additional antibodies for up to five targets

produce discrete and separable effects and provide proof of concept for the development of safer GPCR-targeting

Triple-negative breast cancer (TNBC) is a particularly aggressive and heterogeneous disease with few effective targeted

In all dark-adapted transgenic lines, Gαt1 was targeted to the outer segments, reversing its diffuse

GPCRs represent major drug targets, as indicated by the fact that about 40% of all drugs currently used

Adrenergic receptors on B cells and intracellular β2-ADR downstream molecules (G protein-coupled receptor

PKA can translocate to the nucleus to regulate transcription through the phosphorylation of various targets

class A GPCRs abundantly expressed in pituitary tumors where they represent the main pharmacological targets

sessions: Utilizing new cellular assays to analyze GPCR ligand behavior Predicting activity and in vivo target

GABAB receptors inhibit Ca2+ entry, whereas 5-HT1B receptors target SNARE complexes.

Administration of Exendin-4 to MI rats reduced the infarct size and reversed the aforementioned signaling molecules

operate on the principle of energy transfer between a fluorescent or luminescent donor and acceptor molecules

relevance of these PTMs in the chemokine receptor system which may ultimately allow for new precise targeting

important principles for drug treatment.[24–30] Black was particularly interested in developing drugs that targeted