Advances in structural genomics, coupled with techniques like X-ray crystallography and cryo-electron The genetic variation in GPCRs is extensive; databases like GPCRdb provide a large database of genetic

structure-based drug design platform and enhancing translational medicine capabilities • ‘Venture-like

presence of CaSR autoantibodies that operated as biased allosteric modulators of CaSR, and (g) were likely

Humanity has always sought to live longer and for this, multiple strategies have been tried with varying In this sense, G protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while

The conformation-selective antibody, Fab30, promotes partially activated βarr into the activated-like

revealed that postsynaptic cAMP signaling is required for continuous replacement of synapses throughout life

form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes to fine-tuning

We also showed that the EMC promotes surface expression of C3aR, likely explaining its identification

However, Gpr3-deficient mice display several adverse phenotypes, including elevated anxiety-like behavior

Gs-coupled receptors enriched in SKM has only a limited impact on whole-body glucose homeostasis, most likely

Moreover, advanced AI models like AlphaFold3, which can predict complex protein-molecule interactions

Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune However, intracellular partners linking GPCRs to TASK1 modulation are not yet well-known.

contrast, when the GPR55 receptor is simulated in complex with the selective agonist ML186, agonist-like The all-atom MD simulations reveal that CBD induces conformational changes linked with agonist-bound To contextualize the results we looked into the CB1 receptor in complex with a well-established antagonist

the evolutionary conservation of these residues can lead to the development of drugs that are less likely

can provide a comprehensive understanding of how drugs interact with different receptor regions and link determine the functional consequences of every possible amino acid change at each position in a protein, as well While advancements in structural biology techniques like X-ray crystallography and cryo-electron microscopy