We also take into account the detrimental effect of mutations carried by distinct signalling proteins

Transitioning to study Latrophilins, I decided to test the interaction of neurexins with Latrophilins New Insights Members Torsten Schöneberg and Ines Liebscher present an interactive browser-based application the tethered agonist-dependent activities of all 33 aGPCRs in a suite of transcriptional reporter, G protein PMID: 38608683 The activation profile of different G proteins by ADGRL3 is shown using a collection of PMID: 38311610 Member Dimitris Placantonakis’s identifies extended synaptotagmin 1 as an intracellular interaction

Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and modulates site and the extracellular domains in conformations modulated by a full agonist, BI167107, and a G-protein-biased

Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets

Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets

Although some G-protein coupled receptors (GPCRs) were reported to play roles in osteoblast function,

The G protein and intracellular Ca2+ were detected, respectively, by qPCR and Fluo-4AM Ca2+ fluorescent

a biopharmaceutical company specializing in the discovery and development of new drugs targeting G Protein-Coupled

Chemokine Receptor CXCR3 for Autoimmune Diseases "The chemokine receptor CXCR3 is a seven-transmembrane G-protein-coupled

Numerous intracellular mediators are activated by these G protein-coupled receptors based on several

Numerous intracellular mediators are activated by these G protein-coupled receptors based on several

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface.

platform, which uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled

through the μ opioid receptor GPCR Binders, Drugs, and more Predicting associations between drugs and G protein-coupled Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface.

September 2022 "Given the promising clinical value of allosteric modulators of G protein-coupled-receptors

September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid We considered whether cholesterol, a prominent component of the plasma membrane, limits the ability of Our analyses reveal that cholesterol inhibits phospholipid scrambling by occupying the TM6/7 interface

Biotechnology Canada Ltd, a drug discovery and development company unlocking the therapeutic potential of G Protein-Coupled

They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a lysine

August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors

August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational

A major pan-receptor focus has been to identify GPCR-selective ligands that have bias in G protein-dependent

me great pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled

Gáspár Pándy-Szekeres ) will present and demonstrate the newest resources of the GPCRdb: 1) the new G protein

of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes "A number of G protein-coupled

we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled

to the same GPCR in living cells "β-arrestins mediate regulatory processes for over 800 different G protein-coupled

These disorders are mainly related to the abnormalities in the rod G protein-coupled receptor (GPCR),