Search Results
397 items found for "proteomics"
- Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
A major pan-receptor focus has been to identify GPCR-selective ligands that have bias in G protein-dependent
- RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
me great pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled
- New Resources in GPCRdb
Gáspár Pándy-Szekeres ) will present and demonstrate the newest resources of the GPCRdb: 1) the new G protein
- Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes "A number of G protein-coupled
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
meningitidis and identified 30 N-acyl amides with representative members serving as agonists of the G-protein
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled
- GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor "Modulators of the G protein-coupled
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
These disorders are mainly related to the abnormalities in the rod G protein-coupled receptor (GPCR),
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
to the same GPCR in living cells "β-arrestins mediate regulatory processes for over 800 different G protein-coupled
- Prostaglandin signaling in ciliogenesis and development
Many G-protein-coupled receptors (GPCRs) including EP4 are localized in cilia for modulating cAMP signaling
- Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P 2 Lipids
4,5-bisphosphate (PI(4,5)P2) lipids have been shown to stabilize an active conformation of class A G-protein
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
antagonist and agonist ligands "The CX3C chemokine receptor 1 (CX3CR1), a member of the class A of G Protein-Coupled
- OMass Therapeutics's founder, Carol Robinson, has been awarded the prestigious Louis-Jeantet ...
yesterday for contributions to the field of mass spectrometry and establishing it as method to analyse proteins
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
the gut-brain axis, have entered a strategic research collaboration to identify and validate novel G protein-coupled
- Newly launched antibody libraries put hard-to-drug targets within reach
To target hard-to-drug targets like G protein-coupled receptors (GPCRs), more libraries, including better
- 📰 GPCR Weekly News, November 6 to November 12, 2023
acid derivatives as a new class of GPR34 antagonists Larixol is not an inhibitor of Gαi containing G proteins Immunology Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis TIPE proteins
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
September 2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate
- Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
suppression of gut IEL effector functions linked to the dampening of proximal T cell receptor signaling in a protein-kinase-A-dependent
- Confo Therapeutics Doses First Subjects In Phase 1 Clinical Trial Of CFTX-1554 For The Treatment ...
Belgium – March 10, 2022 – Confo Therapeutics , a leader in the discovery of medicines targeting G-protein
- First in Human: Early-stage COVID therapies hold promise against omicron variant
partner GlaxoSmithKline PLC posted results Dec. 7 demonstrating activity against the omicron spike protein
- Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: Analysis of Diffusion Modes "G protein-coupled
- Comparative study of neuropeptide signaling systems in Hemiptera
Here, 33 neuropeptide precursors and 48 putative neuropeptide G protein-coupled receptor (GPCR) genes
- Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled
- Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
August 2022 "Abstract Sigma receptor is a transmembrane non-GPCR protein expressed mainly in the endoplasmic
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
inflammasome activation in macrophages "The putative medium-chain free fatty acid receptor GPR84 is a G protein-coupled
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization
actin cytoskeleton in regulating the dynamics of the serotonin1A receptor, a crucial neurotransmitter G protein-coupled
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
of behavioral processes and physiological functions in invertebrates through the interaction with G-protein-coupled