Search Results
494 items found for "Bcl-2"
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
September 2022 To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein
- A broad look into the future of systemic sclerosis
September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation
- Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis
September 2022 "Yeast use the G-protein–coupled receptor signaling pathway to detect and track the mating
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways According to the cutoff value, 26.4% (95/360) of patients showed high GPER expression and significant
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
September 2022 "Perception of threats is essential for survival.
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization
September 2022 "The function of the actin cytoskeleton in cellular motility and trafficking has been
- Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
September 2022 "The follicle-stimulating hormone receptor (FSHR) belongs to the glycoprotein hormone
- Interacting binding insights and conformational consequences of the differential activity of...
September 2022 Interacting binding insights and conformational consequences of the differential activity
- Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
September 2022 Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
September 2022 "Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple
- Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a GPCR
September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid
- FSH and bone: Comparison between males with central versus primary hypogonadism
September 2022 "Experimental studies proposed a direct effect of follicle-stimulating hormone (FSH) on
- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies
September 2022 "Research on cancer therapies focuses on processes such as angiogenesis, cell signaling In 2008 (and for the first time in the clinic), the therapeutic benefits of the β-adrenergic receptor
- A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New..
September 2022 A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under
- Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
September 2022 Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
September 2022 Identification and functional characterization of the sulfakinin and sulfakinin receptor
- Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its...
September 2022 Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation
- Identification of hub genes in the subacute spinal cord injury in rats
September 2022 "Background Spinal cord injury (SCI) is a common trauma in clinical practices.
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages
- Immunomodulatory Role of Neuropeptides in the Cornea
September 2022 "The transparency of the cornea along with its dense sensory innervation and resident
- C3aR plays both sides in regulating resistance to bacterial infections
September 2022 "Activation of the complement pathway results in the production of bioactive C3a, a product
- GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer
September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases We computationally docked ~2700 known β2AR ligands to multiple β2AR structures, generating ca 75 000
- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an Through multimodal single-cell CITE- and TCR-sequencing, we detected GLP-1R expression in 29–34% of the