Subacute SCI is mainly characterized by neuronal apoptosis, axonal demyelination, Wallerian degeneration It has been discovered in recent years that inflammatory responses are particularly important in subacute GEO database. The differentially expressed genes (DEGs) and weighted correlation network analysis (WGCNA) were performed Read more at the source #DrGPCR #GPCR #IndustryNews

experimental and simulation approaches, that membrane cholesterol acts as a key regulator of organization, dynamics In addition, we showed that membrane cholesterol stabilizes the serotonin1A receptor against thermal deactivation that our results could have potential implications in structural biological advancements of GPCRs and design of thermally stabilized receptors for drug development." Read more at the source #DrGPCR #GPCR #IndustryNews

for the proper and efficient response of these cells to distinct triggers. During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains We also take into account the detrimental effect of mutations carried by distinct signalling proteins giving rise to syndromes characterized by defects in T cell functionality." Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "The transparency of the cornea along with its dense sensory innervation and resident The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege , in part due to its unique repertoire of resident immune cells. events, and the inflammatory microenvironment in disease. Read more at the source #DrGPCR #GPCR #IndustryNews

Specifically, previous research has identified mechanistically distinct and cell type–specific roles Thus, this review will cover specific roles of C3aR in driving cell type–specific and tissue specific responses during bacterial infections and emphasize the contribution of the C3a–C3aR axis in regulating Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "GPCRs are the most potential targets for drug discovery, however, their role in oncology is underappreciated and GPCR-based anti-cancer drug is not fully investigated. Depletion of GPR108 dramatically inhibited the survival of various cancers. Furthermore, in vitro and in vivo assays demonstrated that GA was dependent on GPR108 to exert anti-cancer Read more at the source #DrGPCR #GPCR #IndustryNews

Quantitative real-time probe-based polymerase chain reaction (qRT-PCR) assays are deployed in order to This can be deduced from the qRT-PCR assays; triggering CB1 receptors amplifies both NR4A1 and NR4A3 The present research demonstrated that 10 nM of ACEA notably amplified mRNA gene expression of NR4A1 Further research is required to fully delineate their role(s)." Read more at the source #DrGPCR #GPCR #IndustryNews

peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic target in diabetes GLP-1R+ cells showed no difference in their TCR-gene usage nor CDR3 lengths. dermatitis. Taken together, the present data demonstrate that T cell activation triggers the expression of functional Read more at the source #DrGPCR #GPCR #IndustryNews

- and ligand specific aGPCR functions using unique tools, and thus establishes a foundation for the development of fine-tuned aGPCR-targeted therapeutics" Read more at the source #DrGPCR #GPCR #IndustryNews

Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis such as exposure to lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology role of the specific arginine residue at position 125 of MRAP2, which affects protein conformation, dimer regulates G protein-coupled receptors helps in elucidating the metabolic pathways involved in metabolic dysfunction and in developing new drugs as specific targets of the MRAP2-PKR2 complex." Read more at the source #DrGPCR #GPCR #IndustryNews

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December 2021 "Geneva, Switzerland, December 17, 2021 – Addex Therapeutics Ltd (SIX: ADXN and Nasdaq : ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, today announced that it has entered into a definitive agreement with Armistice Capital after their date of issuance and will expire six years from their date of issuance. Read more at the source #DrGPCR #GPCR #IndustryNews

December 2021 " Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor Read more at the source #DrGPCR #GPCR #IndustryNews

December 2021 " Tokyo, Japan and Cambridge, UK, 24 December 2021 – Sosei Group Corporation (“ Sosei waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 (“HSR Act”) expired on 22 December As such, the License Agreement became effective on 22 December 2021. million, with the amount to be recognized as revenue in the fourth quarter of the financial year ending December Read more at the source #DrGPCR #GPCR #IndustryNews

December 2021 "Meet Peter McNamara , Ph.D., Tectonic ’s SVP, Head of Research. We’re glad to have Peter's dedication, experience, and passion in building innovative therapeutics." Read more at the source #DrGPCR #GPCR #IndustryNews

Simply put, it represents what we do and why we do it. Read more at the source #DrGPCR #GPCR #IndustryNews

Food and Drug Administration (FDA) approval of TAVNEOS in October 2021. Read more at the source #DrGPCR #GPCR #IndustryNews

of a Scientific Advisory Board comprising international leaders in GPCRs pharmacology, immunology, drug discovery and development for auto-immune diseases" Read more at the source #DrGPCR #GPCR #IndustryNews

example, schools and universities, research centers, governmental institutions, or private companies) Deadlines STSM) We offer short-term scientific mission grants to Ukrainian researchers who have been recently displaced Read more at the source #DrGPCR #GPCR #IndustryNews

ADXN, Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, announced today that it will issue its full-year 2021 financial results on Tim Dyer , CEO, Roger Mills , CMO and Robert Lütjens , Head of Discovery Biology, will provide a business update and review its pipeline during a teleconference and webcast for investors, analysts and media at 16:00 CET (15:00 GMT / 10:00 EST / 07:00 PST) the same day. " Read more at the source #DrGPCR #GPCR

., a clinical-stage global biopharmaceutical company developing novel oral therapeutics to treat a wide range of chronic diseases, today introduced Basecamp Bio, a wholly owned subsidiary dedicated to fueling ShouTi ’s pipeline and pursuing drug discovery partnerships." Read more at the source #DrGPCR #GPCR #IndustryNews

" Read more at the source #DrGPCR #GPCR #IndustryNews

Encouraging Phase 1 results and supportive preclinical package assist in the launch of Phase 2 clinical development Metabolic disorders are a global epidemic1 MONTREAL--(BUSINESS WIRE)--Inversago Pharma Inc. completion of the Phase 1 Clinical Trial for its INV-202 molecule that focuses on treating metabolic disorder Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "GPCRs in Medicinal Chemistry Event 8th RSC / SCI symposium on GPCRs in Medicinal Chemistry Dates Wednesday-Friday, 5th-7th October 2022 Place Evotec Campus Levi-Montalcini, Verona, Italy Downloads and Links Registration closing dates: 6th September – registration against invoice (bank transfers): Tuesday, 6th September 30th September – online registration (card payments)" Read more at the source #DrGPCR