Search Results
521 items found for "Jespers W"
- Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation..
The pathophysiology is not fully understood, but the working hypothesis postulates that a combination We previously demonstrated that a reduction in extracellular pH activates latent TGF-β1, and that TGF-β1 Given the important roles of extracellular pH in the progression of pulmonary fibrosis, we sought to identify whether pH mediates other cellular phenotypes independent of TGF-β1. Here, we report that the Ovarian Cancer G-Protein Coupled Receptor1 (OGR1 or GPR68) has dual roles in
- G protein coupling and activation of the metabotropic GABAB heterodimer
Here, we use molecular metadynamics computations to predict the mechanism by which the inactive GP induces We find that the inactive GP first interacts with TM3, which further leads to the TMD rearrangement and
- Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
Thus, we investigated the regulatory functions of its β-adrenergic-like octopamine receptor (PxOctβ3) frame (ORF) of PxOctβ3 was phylogenetically analyzed, and the levels of expression of the receptor mRNA were A series of octopamine receptor agonists and antagonists were tested against PxOctβ3. We showed that the receptor is a member of the Octβ3 protein family, and an analysis using quantitative Only metoclopramide and mianserin had significant antagonistic effects on PxOctβ3, whereas yohimbine,
- Platelets in the NETworks interweaving inflammation and thrombosis
September 2022 "Platelets are well characterized for their indispensable role in primary hemostasis to Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release NETs were also detected in thrombotic lesions in several disease backgrounds, pointing towards a role The negatively charged DNA within NETs provides a procoagulant surface, and in particular NET-derived In this review, we will discuss the interplay between platelets and NETs and the potential of this alliance
- Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstream In this article, we describe the signal transduction elements that regulate PLC gene expression.
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
We investigated the influence of specific inhibitors of G protein-coupled receptors (GPCR), endocytosis We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1. The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA KD of S2R/TMEM97 significantly reduced the uptake, which was accompanied by the nullification of the We further showed the intracellular trafficking and targeting process of F-Hst1, in which early endosome
- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane Here, we describe the cryo-EM structure of Cya bound to a stabilizing nanobody at 3.6 Å resolution.
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
This study aimed to investigate the specific molecular mechanism by which CCR9/CCL25 modulates malignant Methods Immunohistochemistry staining and RT–qPCR analyses were performed to detect the correlation In vitro , SACC cell proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation , and cell migration and invasion were detected by wound healing and transwell assays. Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction
- Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
via opioid receptor-dependent activation of EGFR "Background Fentanyl is an opioid analgesic and is widely Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after
- Sign Up Now!
🌐 🤝 We want to bring closer the #GPCR community! Join the Dr. ➡️ https://www.ecosystem.drgpcr.com/explore-individuals #gpcr #drgpcr
- Dr. GPCR Summit 2022 is coming!
➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-summit-2022 #gpcr #drgpcr
- Join Us Today!
➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr
- Trainees, this is for you...
Would you like to develop your presentation skills? Give a talk or present a poster at the Dr. ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr
- Dr. Rosie Dawaliby Podcast!
We're very excited to announce the next episode of the Dr. GPCR podcast! 🥁 Drum rolls, please! Our guest is the wonderful Dr. Rosie Dawaliby! Watch the full video with a Dr. GPCR Ecosystem paid membership ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-84-with-rosie-dawaliby
- Join Us Now!
🌟 We're so excited about our upcoming Dr. GPCR Summit 2022. Do you want to be part of it? Our Summit is FREE for all Ecosystem site members, which is also free! Join us now ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-summit-2022 #gpcr #drgpcr
- Addex Raises $10 Million In Equity Financing
the form of 625,367 American Depositary Shares (“ADSs”) at a gross purchase price of $6.50 per ADS, which Additionally, Addex has agreed to issue to Armistice Capital unregistered warrants to purchase up to 9,230,772 shares in the form of 1,538,462 ADSs (the “Unregistered Warrants”), as well as unregistered pre-funded warrants to purchase up to 5,478,570 shares in the form of 913,095 ADSs (the “Unregistered Pre-Funded Warrants” and together with the Unregistered Warrants, the “Warrants”) in a concurrent private
- Learn about Dr. GPCR Ecosystem!
We have #GPCR News, Learning Center, Events, and more to discover! Learn More HERE ➡️ https://www.ecosystem.drgpcr.com/learning-center #gpcr #drgpcr
- Addex Therapeutics CEO Tim Dyer: There is a $4-bil market opportunity in dyskinesia
January 2022 "Watch our CEO Tim Dyer on AlphaStreet. In his interview, Mr.
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
The companies have been working together since 2016 and in 2019, Sanofi in-licensed Exscientia ’s novel
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
Disease Rating Scale (UHDRS®) Total Maximal Chorea (TMC) score from baseline to the average score at weeks
- Sosei Heptares Announces Antitrust Clearance of License Agreement with Neurocrine Biosciences
Neurocrine Biosciences , Inc. (“ Neurocrine Biosciences ”) announced 22 November 2021, the applicable waiting With completion of the applicable waiting period under the HSR Act, under the terms of the License Agreement
- Meet Peter McNamara, Ph.D., Tectonic’s SVP, Head of Research
We’re glad to have Peter's dedication, experience, and passion in building innovative therapeutics."
- Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
She has held numerous senior roles at the University of Oxford , where she is currently Professor of
- Verily links up with Sosei Heptares for GPCR drug discovery
Among those hitching their wagons to that star are Verily and Sosei Heptares , which have struck a research The financial details of the strategic collaboration weren’t released, but Sosei Heptares ’ past two
- Learn more about Neurocrine Biosciences with their new video
January 2022 "The Neurocrine Biosciences story puts into words what makes the work and people at Simply put, it represents what we do and why we do it.
- ChemoCentryx Announces EU Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated ...
., Jan. 19, 2022, today announced that TAVNEOS® (avacopan) has been approved within the European Union TAVNEOS will receive marketing authorization in all member states of the European Union, as well as in
- Novo Nordisk moves to strengthen obesity efforts
January 2022 "After securing FDA approval for Wegovy last year, Novo Nordisk is strengthening its position Under the joint research plan, the Danish giant will work with EraCal to identify novel drug targets
- Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with ...
golden age' of prolific drug target GPCR with pioneer as co-founder "J an 27, 2022 07:00am Septerna wants years of experience with the target and analogizes the search for new drugs to oil drilling around the world