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Here, 33 neuropeptide precursors and 48 putative neuropeptide G protein-coupled receptor (GPCR) genes

Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: Analysis of Diffusion Modes "G protein-coupled

In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled

To target hard-to-drug targets like G protein-coupled receptors (GPCRs), more libraries, including better

, Belgium – March 10, 2022 – Confo Therapeutics, a leader in the discovery of medicines targeting G-protein

August 2022 "Abstract Sigma receptor is a transmembrane non-GPCR protein expressed mainly in the endoplasmic

partner GlaxoSmithKline PLC posted results Dec. 7 demonstrating activity against the omicron spike protein

Using purified Fzd proteins reconstituted in lipid nanodiscs, we investigated the factors that promote

We showed that the receptor is a member of the Octβ3 protein family, and an analysis using quantitative

actin cytoskeleton in regulating the dynamics of the serotonin1A receptor, a crucial neurotransmitter G protein-coupled

inflammasome activation in macrophages "The putative medium-chain free fatty acid receptor GPR84 is a G protein-coupled

of behavioral processes and physiological functions in invertebrates through the interaction with G-protein-coupled

G protein-coupled receptors (GPCRs) are integral to cellular signaling, influencing a wide array of physiological

silicon platform, announced a strategic collaboration to discover therapeutic antibodies against G protein-coupled

rodent model of 3-day recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein

Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein

Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because

A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled

September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases

November 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed

G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.

β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs

Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic studies "G protein-coupled

G protein-coupled receptor pharmacology - insights from mass spectrometry. The Illuminating the Understudied Druggable Proteome Conference. Associate Scientist, Protein Science. Explore Dr. GPCR Ecosystem

We show that locally restricted suppression of postsynaptic cAMP levels or of cAMP-dependent protein-kinase

To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination

critical component in multiple immune signaling processes and is dependent on activation by Ras and G protein-coupled

Currently, attention was mainly paid to biased signaling modulators targeting G protein-coupled receptors