Search Results
397 items found for "proteomics"
- PI(4,5)P 2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-c
Using purified Fzd proteins reconstituted in lipid nanodiscs, we investigated the factors that promote
- Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
We showed that the receptor is a member of the Octβ3 protein family, and an analysis using quantitative
- Sosei Heptares Enters Antibody Discovery Agreement with Twist Bioscience to Discover and Develop ...
silicon platform, announced a strategic collaboration to discover therapeutic antibodies against G protein-coupled
- Precise druggability of the PTH type 1 receptor
Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because
- A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein
- Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
rodent model of 3-day recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases
- GPCR voltage dependence controls neuronal plasticity and behavior
G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.
- Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
November 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly
We show that locally restricted suppression of postsynaptic cAMP levels or of cAMP-dependent protein-kinase
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic studies "G protein-coupled
- HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...
critical component in multiple immune signaling processes and is dependent on activation by Ras and G protein-coupled
- TLR4 biased small molecule modulators
Currently, attention was mainly paid to biased signaling modulators targeting G protein-coupled receptors
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled
- Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembra
G protein-coupled receptors (GPCRs) are among the most promising drug targets.
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
They recognize two types of G protein-coupled receptors (LPARs): LPA1-3 receptors and LPA4-6 receptors
- GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence
- In Vitro and In Silico Characterization of Kurarinone as a Dopamine D 1A Receptor Antagonist and ...
Alterations in the expression and/or activity of brain G-protein-coupled receptors (GPCRs) such as dopamine
- β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
G protein-coupled receptors (GPCRs) have been shown to play integral roles in Alzheimer's disease pathogenesis
- Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
conducted to elucidate binding mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR protein
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
considered that TNBC is an estrogen-independent breast cancer, while a new estrogen receptor, namely G protein-coupled
- Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation
Engineered G protein-coupled receptors (GPCRs) are commonly used in chemogenetics as designer receptors
- Adhesion GPCR Consortium Newsletter - May 2024
the tethered agonist-dependent activities of all 33 aGPCRs in a suite of transcriptional reporter, G protein PMID: 38608683 The activation profile of different G proteins by ADGRL3 is shown using a collection of
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
We demonstrate that the chemoreceptor genes, srg-36 and srg-37 , which encode G protein-coupled receptors
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
The cytoskeletal protein filamin A (FLNA) directly interacts with both somatostatin receptor type 2 (