Search Results
424 items found for "Chemokine receptor"
- VIB spin-off Confo Therapeutics Enters Collaborative Agreement with Regeneron
uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors
- Orion Shares New Data on its Latest Best-in-Class Drug Candidate
, a drug discovery and development company unlocking the therapeutic potential of G Protein-Coupled Receptors
- The Gluopsins: Opsins without the Retinal Binding Lysine
They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a lysine
- Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...
Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune outcomes suggest that LPA and several neurotransmitters impact MN IME via Gαi/o/Gαq-protein-coupled receptors
- 📰 GPCR Weekly News, October 16 to 22, 2023
Signaling β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor distinct inflammatory responses State-dependent dynamics of extramembrane domains in the β2 -adrenergic receptor
- RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled receptors
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the
- Drug Discovery Picks Up the Pace, Stays on Target
screening, drug efficacy analyses, and toxicity studies; technologies that stabilize G protein–coupled receptors
- GPCR Signaling and mTORC1 Regulation
will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
June 2022 "G protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play
- Positive Recommendation for Use of TAVNEOS™ (avacopan) in ANCA Vasculitis Adopted by European ...
authorization for the Company’s TAVNEOS (avacopan), an orally administered selective complement 5a receptor
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
axis, have entered a strategic research collaboration to identify and validate novel G protein-coupled receptor
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs: G protein-coupled receptors p62: sequestosome 1; STAT: signal transducer and activator of transcription; TACR1/NK1R: tachykinin receptor
- PI(4,5)P 2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-c
September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-receptors
- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in
- Addex's strategic partner The Janssen Pharmaceutical Companies of Johnson & Johnson, Inc. has...
ADX71149 is a selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulator
- Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein coupled receptors
- Effect Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells
In conclusion, 10μM THC and CBD altered the differentiation of HC11 cells, in part via the CB2 receptor
- Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs
- Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, and a G protein-coupled receptor
- Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent ...
specific LAT-1-positive neurons and first insights into the genetic network that is modulated by the receptor
- Applications of Cryo-EM in small molecule and biologics drug design
crystallography, by cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors
- HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...
in multiple immune signaling processes and is dependent on activation by Ras and G protein-coupled receptors
- Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890
October 2022 "Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors
- GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...
G protein-coupled receptor 3 (GPR3) belongs to the class A rhodopsin-type GPCR family and is highly expressed
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
We demonstrate that the chemoreceptor genes, srg-36 and srg-37 , which encode G protein-coupled receptors