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439 items found for "Dr. Albert Kooistra"

  • Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Comparison of infectious complications with BCMA-directed therapies in multiple myeloma

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Welcoming Remarks | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Welcoming Remarks < Previous Session Next Session >

  • Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Plenary Lecture Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Abstract Only Available for AGPCR24 Attendees About Jin-Peng Sun "Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the ligand identification, physiological functions and molecular mechanism of biased signaling of GPCRs. Our first main research aspect is the identification of endogenous ligand of GPCRs. We have identified the receptor subfamily to sense the steroid hormones. For instance, membrane receptor GPR97 is able to sense glucocorticoid to mediate its rapid actions, the progesterone and 17-hydroxyprogesterone membrane receptor are GPR126. We also identified DHEA, DHEAS and DOC are endogenous ligands of GPR64 etc (Nature, 2021a, Nat Chem Biol 2022, PNAS 2022b). Our second main research aspect is dissecting the molecular mechanism underlying sensation of force, ordor, itch and taste by GPCRs. We have elucidated the mechanism of receptors' perception of itch, olfactory and force (Nature 2021b, 2022a, 2022b, 2023a, 2024). Our third main research aspect is working mechanism of GPCR. For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking theory” etc. to explain the arrestin mediated GPCR functions (Nature communications, 2015, 2021, 2022; PNAS 2021, Molecular Pharmacology, 2017; Recommended by Faculty 1000, Nature Chemical Biology 2018). We identified that arrestin can mediated AT1R/TRPC3 or M3R/TRPC3 coupling by forming a complex of AT1R/β-arrestin-1/PLCγ/TRPC3 or M3R//β-arrestin-1/TRPC3 (Nature communications, 2017, Nature communications, 2018). We also identified that orphan receptor GPR64 forms complex with β-arrestin-1 and CFTR at apical membrane of efferent ductulus to regulate the salt/water metabolism (eLife 2018, Faculty 1000 recommendation). Our fourth main research aspect is ligand coding mechanisms and structural aided drug discovery of GPCR. We have decoded the mechanisms underlying recognition of fish oil (unsaturated fatty acids) and other lipids by GPCRs (Science 2023, Science Advance 2021, PNAS 2023, Nature Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell 2021, 2023, Nature 2023b), bile acids or its derivatives by GPCRs (Nature 2020)." Jin-Peng Sun on the web Google Scholar LinkedIn < Previous Session Next Session >

  • Closing remarks | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Closing remarks < Previous Session Next Session >

  • Travel Tips for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    TRAVELING TIPS Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Register DO's and DONT's for travelers in Mexico Mexico travel advice *Travelers are encouraged to consult their country's embassy advisories as they may differ from the one posted above. The Canadian embassy provides a comprehensive list. Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR workshop 2024 and its preliminary program. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Abstract Submission Submit your research abstracts following our guidelines to present at the conference. Up Logo Contest Enter our logo contest for a chance to have your design represent the upcoming event.

  • Our Sponsors for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    OUR SPONSORS Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Sponsor Us Platinum Sponsors Bronze Sponsors Collaborating partners Contact us for sponsorship Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR workshop 2024 and its preliminary program. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Abstract Submission Submit your research abstracts following our guidelines to present at the conference. Up Traveling Tips Find essential tips about Mexico City, including transportation options and local insights.

  • Abstract Submission Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    ABSTRACT SUBMISSION Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Submit your Abstract Here Register for the Adhesion GPCR 2024 [ Registration extended until September 15th ] Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR Workshop 2024 and its preliminary program. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Traveling Tips Find essential tips about Mexico City, including transportation options and local insights. Up Logo Contest Enter our logo contest for a chance to have your design represent the upcoming event.

  • Sponsorship Prospectus for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    SPONSORSHIP PROSPECTUS Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Sponsor We are delighted to present the sponsorship opportunities available for Adhesion GPCR Workshop 2024, a premier scientific meeting bringing together leaders and innovators in G Protein-Coupled Receptor (GPCR) biology. Adhesion GPCR Workshop 2024 will take place on October 23-25, 2024 at Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (known as Cinvestav) in Mexico City, offering a dynamic platform for knowledge exchange, collaboration, and networking. About the Adhesion GPCR Workshop 2024: Adhesion GPCR Workshop 2024 is a high-profile expert conference, attracting attendees from across the globe. Our agenda includes keynote presentations, panel discussions, workshops, and networking sessions covering the latest advancements and challenges in Membrane Receptor biology. This event provides an unparalleled opportunity for sponsors to showcase their commitment to scientific excellence and innovation. Audience Profile: Basic Scientists Academics Clinical Scientists Industry Professionals Health Professionals Policy Makers Students Why Sponsor Adhesion GPCR Workshop 2024? Align your brand with scientific excellence and innovation. Showcase your products, services, and research initiatives to a targeted audience. Enhance brand visibility and recognition among key stakeholders in the field. Network with leading professionals and decision-makers in the industry. Support the advancement of knowledge and collaboration within the scientific community. Sponsorship Opportunities Platinum Sponsor Exclusive recognition as the Platinum sponsor in all promotional materials. Prime placement of company logo on event website, signage, and marketing collateral. Opportunity to deliver opening remarks or introduce keynote speakers. Complimentary exhibition booth in a prominent location at the event venue. Recognition in press releases and media coverage. Complimentary registration for 3 representatives. Opportunity to be designated in print on the 1 st ever “aGPCR Excellence and Mentoring Award” Customized sponsorship package available upon request. Gold Sponsor Prominent recognition as a Gold sponsor in all promotional materials. Company logo displayed on event website, signage, and marketing collateral. Opportunity to sponsor a keynote session or panel discussion. Recognition during opening and closing remarks. Complimentary exhibition booth at the event. Complimentary registration for 2 representatives. Customized sponsorship package available upon request. Silver Sponsor Recognition as a Silver sponsor in all promotional materials. Company logo displayed on event website and signage. Opportunity to sponsor a workshop or networking session. Recognition during opening and closing remarks. Complimentary registration for 1 representative. Customized sponsorship package available upon request. Bronze Sponsor Recognition as a Bronze sponsor in all promotional materials. Company logo displayed on event website.Recognition during opening and closing remarks. Additional Sponsorship Opportunities: Networking Reception Sponsorship Conference Cup and T-Shirt Sponsorship Conference Bag Sponsorship Lanyard Sponsorship Coffee Break Sponsorship Customized Opportunities Available Contact us for sponsorship Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR workshop 2024 and its preliminary program. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Abstract Submission Submit your research abstracts following our guidelines to present at the conference. Up Traveling Tips Find essential tips about Mexico City, including transportation options and local insights.

  • Logo Contest for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    LOGO CONTEST Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Register Rules for the logo contest Design must be based on “Alebrijes” [ah-leh-bree-hez], which are chimeric creatures from Mexican folklore AND contain adhesion GPCRs Avoid copyrighted material unless a CC BY / open-use license has been acquired or generated (Adobe Stock, etc). The Consortium must be free to use the design. Requirements: Resolution 300 ppi max, JPEG/TIFF/EPS/PNG/PDF formats, 5MB max Open to all adhesion GPCR community members. Artist-scientists must be registered to attend the adhesion GPCR workshop 2024 in Mexico City. The contest deadline is August 15th, 2024, 11:59 PM CST (designs received after the deadline will not be considered) Designs or inquiries should be sent to this email The prize for the selected design will include free registration and more! Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR workshop 2024 and its preliminary program. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Abstract Submission Submit your research abstracts following our guidelines to present at the conference. Up Traveling Tips Find essential tips about Mexico City, including transportation options and local insights.

  • Complimentary Lunch | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Complimentary Lunch < Previous Session Next Session >

  • Illuminating Functional Selectivity and Allosterism at GPCRs.

    Date & Time Saturday, November 4th / 11:30 AM Abstract Coming Soon About Stéphane Laporte "Dr. Stéphane Laporte on the web Laporte Lab McGill University LinkedIn Dr.

  • A journey from Duke to McGill along the dopamine circuit

    In 1999, back in France, Dr. Brunos Giros on the web The Douglas Research Centre McGill University Pubmed Google Scholar LinkedIn Dr

  • Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq

    Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

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