January 2022 "G-protein-coupled receptors’ star has been on the rise in biotech in recent years as researchers

as co-founder "Jan 27, 2022 07:00am Septerna wants to spark a second golden age in G-protein-coupled receptor

regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells GLP-1 and GIP receptors mobilization when combined with propranolol Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor

post-translational processing, release from dense core vesicles, and ability to activate G-protein-coupled receptors

TRV045 is the Company’s novel S1P1 receptor modulator being developed as a potential treatment for diabetic

biopharmaceutical company with an innovative approach to drug discovery based on targeting G Protein Coupled Receptors

company specializing in the research and development of innovative drugs targeting G Protein-Coupled Receptors

switch controlling the apico-basal distribution of the GPCR smoothened "The oncogenic G-protein-coupled receptor

In one example, to study a G protein coupled receptor (GPCR), we used one antagonist as probe and multiple

Dipraglurant selectively targets the metabotropic glutamate receptor subtype 5 (mGlu5) through allosteric

pain-relieving compounds that, like morphine and other drugs, provide relief via activation of opioid receptors

biopharmaceutical company specializing in the discovery and development of new drugs targeting G Protein-Coupled Receptors

drug discovery and development, announced today that it has moved a selective and potent M4 muscarinic receptor

September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid

results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor

Signaling β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor distinct inflammatory responses State-dependent dynamics of extramembrane domains in the β2 -adrenergic receptor

The targets, including G protein-coupled receptors (GPCRs), intracellular protein complexes and solute

The vision is to develop novel muscarinic receptor agonists for schizophrenia and other neuropsychiatric

They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a lysine

, a drug discovery and development company unlocking the therapeutic potential of G Protein-Coupled Receptors

uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors

pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled receptors

October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the

screening, drug efficacy analyses, and toxicity studies; technologies that stabilize G protein–coupled receptors

will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor

June 2022 "G protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play

The result suggested that, in contrast to other proton-sensitive channels and receptors, GPR68 did not Molecular basis of proton-sensing by G protein-coupled receptors.

authorization for the Company’s TAVNEOS (avacopan), an orally administered selective complement 5a receptor