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574 items found for "Orphan GPCR"
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
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- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
ligands "The CX3C chemokine receptor 1 (CX3CR1), a member of the class A of G Protein-Coupled Receptors (GPCR patterns that characterize a functional state to contribute to the understanding of the complexity of the GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Functional modulation of PTH1R activation and signaling by RAMP2
ubiquitously expressed membrane proteins that associate with different G protein–coupled receptors (GPCRs ), including the parathyroid hormone 1 receptor (PTH1R), a class B GPCR and an important modulator of These data uncover a critical role of RAMPs in the activation and signaling of a GPCR that may provide a new venue for highly specific modulation of GPCR function and advanced drug design." Read more at the source #DrGPCR #GPCR #IndustryNews
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
September 2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate Serotonin1A receptors are important members of the GPCR family and are implicated in neuropsychiatric To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking results bring out the interdependence of cholesterol and actin cytoskeleton in regulating diffusion of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
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- Interacting binding insights and conformational consequences of the differential activity of...
Notably, while CBD is able to antagonize some GPCRs in the endocannabinoid system, it also seems to activate we investigate the interacting determinants of CBD in two closely related endocannabinoid-activated GPCRs the CBD ligand in the GPR55 receptor elicit conformational changes associated with antagonist-bound GPCRs The all-atom MD simulations reveal that CBD induces conformational changes linked with agonist-bound GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
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- FSH and bone: Comparison between males with central versus primary hypogonadism
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- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies
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- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
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- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
physiological functions in invertebrates through the interaction with G-protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
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- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
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- Identification of hub genes in the subacute spinal cord injury in rats
Finally, the relative mRNA expression level of central genes was verified by RT-PCR." Read more at the source #DrGPCR #GPCR #IndustryNews
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
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- Immunomodulatory Role of Neuropeptides in the Cornea
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- C3aR plays both sides in regulating resistance to bacterial infections
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- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
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- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
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- C1-inhibitor influence on platelet activation by thrombin receptors agonists
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- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
September 2022 "The GPR15 receptor is a G protein-coupled receptor (GPCR), which is activated by an endogenous Read more at the source #DrGPCR #GPCR #IndustryNews
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
The C5aR1 is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that Read more at the source #DrGPCR #GPCR #IndustryNews
- Chemerin Forms: Their Generation and Activity
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- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
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- Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand...
Three G-protein coupled receptors (GPCRs) for galanin have been discovered, which is the focus of efforts Read more at the source #DrGPCR #GPCR #IndustryNews
- Neurotransmitters: Potential Targets in Glioblastoma
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- Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by...
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- Platelets in the NETworks interweaving inflammation and thrombosis
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