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452 items found for "Stefano Moro"
- A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
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- Nanobodies: New Dimensions in GPCR Signaling Research
All the above lightly represent the potential applications of Nbs to facilitate the development of more To know more about this report check this link. References: Jin, B.
- 📰 GPCR Weekly News, February 19 to 25, 2024
G-protein coupled receptor promotes the restoration of tension in epithelial cells GPCR Binders, Drugs, and more the round: SMA-like copolymers and SMALPs as a platform for investigating GPCRs Reviews, GPCRs, and more
- Co-activation of GPCRs facilitate GIRK-dependent current
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- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
For this reason, DL models generally require more computational resources (such as powerful GPUs) and and their associations: open-access databases from experimental labs and new AI techniques will allow more regulatory bodies will likely increase in the coming years and will facilitate the creation of larger and more
- Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor
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- Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin...
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- Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK...
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- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
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- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
The remaining non-sensory receptors, with functions more readily linked to pathology, are currently the interface for these GPCRs makes modulation with small molecule drugs, when they can be identified, much more Orion’s CCR2 antagonist analog (OB-004), discovered in only 6 months, is considerably more potent than and more central role for in silico methodology and AI in GPCR drug discovery. For more information, follow Orion Biotechnology on LinkedIn or visit www.orionbiotechnology.com.
- New role of β-arrestins in MOR signaling
EOPs): β-endorphin, enkephalins and dynorphins, and four opioid receptors (ORs): μ-opioid receptor (MOR Therefore to understand better the functions of arrestins in MOR signaling, Shiraki et al., explored the function of β-arrestin 2 in MOR signaling using the SH-SY5Y cell line that endogenously expresses MOR and was modified through CRISPR/Cas9 to knock out β-arrestin 1 and 2 gene expression. If you are interested in learning more about the molecular details of this study, you can consult the
- Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...
It is predicted that more than 50 GPCRs are expressed in the liver.
- 📰 GPCR Weekly News
GPCR Binders, Drugs, and more Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Reviews, GPCRs, and more Species dependence of A3 adenosine receptor pharmacology and function.
- Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled ...
Because there are many more GPCRs than effectors, mutations in different receptors could perturb signaling
- Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
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- Adhesion GPCR Consortium Newsletter - May 2024
adhesion molecules that also happened to be targeted by the same spider toxin as latrophilins, were a more As much as I was shocked that I wasn’t asked if I was a student or a PI, I was more proud to say that
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
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- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
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- 📰 GPCR Weekly News, January 30 to February 5, 2023
GPCR Binders, Drugs, and more Ligands selectively tune the local and global motions of neurotensin receptor Reviews, GPCRs, and more Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and
- A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent ...
It is known that when Brd4 is activated by phosphorylation, it binds more readily to acetylated histones
- Odorant receptors – a bit of smell for drug discovery
expression is quite stable, the number of ORs expressed in different human tissues is highly variable from more cells (Maßberg D. and Hatt H. 2018) which implies that heterologous expression of ORs is generally more
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
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- 📰 GPCR Weekly News, July 3 to 9, 2023
GPCR Binders, Drugs, and more Rational design of highly stabilized and selective adrenomedullin analogs
- 📢 GPCR Update: August 19-25, 2024 | Thrilling Announcement: New Pharmacology Course Dates & Exclusive Discounts Inside!
cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling GPCR Binders, Drugs, and more
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
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- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
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- Overview of adhesion GPCRs self-activation
interactions between the last eight αH5 residues of each G protein with the receptor showed that there are more and polar interactions with the receptor and the αH5 tilt of G12 towards TM3/TM5 of the receptor is more
- Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
conformational sampling in advance of docking or receptor conformational adjustment after docking are more