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565 items found for "class C GPCR"
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
pentan-3-yl)-1-cyclopentyl-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamide hydrochloride) of this GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Exploring pharmacological inhibition of G q/11 as an analgesic strategy
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- RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. " Read more at the source #DrGPCR #GPCR
- TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...
The expression markers related to odontoblastic differentiation of hDPSCs were observed by qPCR and chemical The G protein and intracellular Ca2+ were detected, respectively, by qPCR and Fluo-4AM Ca2+ fluorescent Read more at the source #DrGPCR #GPCR #IndustryNews
- A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in...
therapeutic targets in Uterine Corpus Endometrial cancer "Adhesion G protein-coupled receptors (adhesion GPCRs ), as a member of the G protein-coupled receptors (GPCRs) superfamily, have gradually entered the field The structure, function, and involvement of adhesion GPCRs in cancer development have been discussed alsooneofthemostcommonfemalereproductivesystemtumors, but there are few pieces of research related to adhesion GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Helix 8 in chemotactic receptors of the complement system
crystal structures of inactive C5aR1 in terms of an inverted orientation of helix H8, unobserved in other GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
A major pan-receptor focus has been to identify GPCR-selective ligands that have bias in G protein-dependent Read more at the source #DrGPCR #GPCR #IndustryNews
- Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells...
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- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
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- Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
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- C1-inhibitor influence on platelet activation by thrombin receptors agonists
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- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
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- Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand...
Three G-protein coupled receptors (GPCRs) for galanin have been discovered, which is the focus of efforts Read more at the source #DrGPCR #GPCR #IndustryNews
- Neurotransmitters: Potential Targets in Glioblastoma
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- Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by...
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- Platelets in the NETworks interweaving inflammation and thrombosis
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- Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
September 2022 "Given the promising clinical value of allosteric modulators of G protein-coupled-receptors (GPCRs ), mechanistic understanding of how these modulators alter GPCR function is of significance. Read more at the source #DrGPCR #GPCR #IndustryNews
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
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- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
September 2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate Serotonin1A receptors are important members of the GPCR family and are implicated in neuropsychiatric To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking results bring out the interdependence of cholesterol and actin cytoskeleton in regulating diffusion of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
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- Interacting binding insights and conformational consequences of the differential activity of...
Notably, while CBD is able to antagonize some GPCRs in the endocannabinoid system, it also seems to activate we investigate the interacting determinants of CBD in two closely related endocannabinoid-activated GPCRs the CBD ligand in the GPR55 receptor elicit conformational changes associated with antagonist-bound GPCRs The all-atom MD simulations reveal that CBD induces conformational changes linked with agonist-bound GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
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- FSH and bone: Comparison between males with central versus primary hypogonadism
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- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies
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- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
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- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
physiological functions in invertebrates through the interaction with G-protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
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- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
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