Principles of Pharmacology in Drug Discovery II Advanced Methods for the Optimization of Candidate Selection Dr Advanced Methods for the Optimization of Candidate Selection Valid for 6 months Select Subscribe to Dr

Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Registration & Coffee with light breakfast < Previous Session Next Session >

Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling More from Dr GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Scott Leiser on the web University of Michigan Pubmed ResearchGate LinkedIn Dr.

Dr. Heidi Hamm on the web The Hamm Lab Vanderbilt School of Medicine Pubmed Google Scholar LinkedIn Twitter Dr

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Coffee Break with pastries announcement of the aGEM award Complimentary < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Mexico City Nocturnal Tour, Food and drinks Coming Soon < Previous Session Next Session >

Sexton is also a co-founder of Septerna Inc. " Patrick Sexton on the web CCeMMP Monash University Dr.

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session IX / Technology capsule: Light on aGPCR signaling and function NovoiSMART - A new platform for GPCR antibody drug discovery Abstract Developing monoclonal antibody drugs against GPCRs and other multi-pass transmembrane targets, such as ion channels, remains a significant challenge. Novoprotein developed a NovoiSMART technology, utilizing mRNA-based immunization, which can overcome these obstacles by producing high-quality antibodies that more accurately mimic natural protein structures. This approach contrasts with other antigen forms like peptides or DNA, which face limitations in structural integrity and immunogenicity. mRNA technology, demonstrated in the success of COVID-19 vaccines, is emerging as a promising method for antibody discovery. Several case studies of GPCR and other multi-pass transmembrane targets are presented, including GPRC5D, Claudin 6 and Napi2b. These studies show that mRNA immunization yields higher antibody titers and greater epitope diversity compared to other methods. These examples underscore the potential of NovoiSMART technology in developing highly specific antibodies for complex targets, with implications for overcoming challenges like drug resistance and tumor escape. About Gavin Zhang Gavin is a currently a director of business and operations at Novoprotein Scientific. His research experience includes phylogenetics and cancer epigenetics. Gavin Zhang on the web LinkedIn < Previous Session Next Session >

The Ramsey Lab Amy Ramsey on the web University of Toronto Pubmed Google Scholar LinkedIn Twitter Dr.