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521 items found for "Jespers W"
- Third Rock pushes newest fund over $1B line as it marks 15 years in venture capital
its 15th year, Third Rock Ventures announced its sixth fund today — and largest one by far — at a whopping
- Orion Shares New Data on its Latest Best-in-Class Drug Candidate
Protein-Coupled Receptors (GPCRs), today announced that it will be presenting important new data at both LSX World Congress and TIDES USA 2022 conference, taking place this week – May 10-12, 2022.
- Crinetics Presents Clinical And Research Results At ENDO 2022
adrenal hyperplasia (CAH) and other conditions driven by excess adrenocorticotropic hormone (ACTH), were
- Neurocrine Biosciences Presents Data on Treatment of Adolescent Patients with Classic Congenital ...
patients with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD), which
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,
- Michel Bouvier appointed Knight of the Ordre national du Québec
It has been awarded annually since 1985 to distinguished individuals who have strived, in an exceptional way, to enhance Quebec’s image.
- Inversago Pharma appoints Glenn S. Vraniak as Chief Financial Officer
served as an executive in various innovative healthcare and technology companies including GE Capital, where
- AcroScreen co-founder Margaux Duchamp has been selected as a 30 under 30 Europe Forbes ranking 2022
May 2022 "We are thrilled to announce that our co-founder Margaux Duchamp has been selected as a 30
- Targeting the M1 muscarinic receptor in neurodegenerative disease
Director at Sosei Heptares , recently presented at the Keystone Symposia GPCR Conference, a summary of work
- GPCR Therapeutics Expands Scientific Advisory Board
Jon Wigginton will provide scientific expertise to support the company’s research and clinical development
- Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders with ...
Disorders with Tim Dyer Addex Therapeutics " Tim Dyer is the Co-Founder and CEO of Addex Therapeutics , which
- Modulation of Striatal Adenosinergic Function by HTL0041178, a Selective GPR52 Agonist
project director in our Translational Medicine department, recently presented this important pre-clinical work This work highlights an important interplay between the adenosinergic and dopaminergic systems and suggests
- Confo Therapeutics Doses First Subjects In Phase 1 Clinical Trial Of CFTX-1554 For The Treatment ...
, a debilitating condition caused by damage to the nerves outside of the brain and spinal cord, for which
- Illuminating the draggable GPCR-ome
https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe
- Dr. Juan José Fung - Dr. GPCR Podcast
GPCR Podcast is back this week with a brand new episode. Our guest is none other than Dr. Stay tuned as the episode will be released later this week. Subscribe today!
- Dr. Marta Filizola - Dr. GPCR Podcast
GPCR Podcast, we have none other than Dr. Marta Filizola! Subscribe to the podcast today and get notified when new episodes are released! https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #podcast
- Unconventional GPCR-PKA Communication in the Hedgehog Pathway
https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe
- Dr. Josephine (Pina) Cardarelli - Dr. GPCR Podcast
GPCR Podcast, we have Dr. Pina Cardarelli, CSO of GPCR Therapeutics. Subscribe to the podcast today and get notified when new episodes are released!
- AELIS PHARMA launches their IPO for €25 million
February 2022 "We are proud to announce the success of our IPO!
- Trevena Announce Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu ...
Trevena is eligible to receive future success payments upon approval and commercialization milestones, as well adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom
- Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and ...
Protein-Coupled Receptor Homo- and Heterodimer Information flow from a source to a receiver becomes informative when oligomers provides the structural basis for organizing distinct cell compartments along the plasma membrane where Here, we summarize evidence that supports these conjectures, fostering new ideas about the physiological
- Mark Schmeizl - Dr. GPCR Podcast
Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast
- Learn more about Neurocrine Biosciences with their new video
January 2022 "The Neurocrine Biosciences story puts into words what makes the work and people at Neurocrine Simply put, it represents what we do and why we do it.
- A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent ...
The D1 receptor (D1R) is a Gαs/olf-coupled GPCR which activates a cAMP/PKA/DARPP-32 signalling cascade It is known that when Brd4 is activated by phosphorylation, it binds more readily to acetylated histones Here, we demonstrate that in adult rats, inhibition of BET proteins with the bromodomain inhibitor JQ1 suppressed the expression of ~25% of D1R-upregulated genes, while also increasing the expression of Finally, we report that JQ1 treatment downregulated expression of many GPCRs and also impaired ERK1/2
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
Retinitis pigmentosa (RP) is a group of hereditary degenerative diseases affecting 1 of 4000 people worldwide and being the most prevalent cause of visual handicap among working populations in developed countries
- Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
This study compares performance when docking ligands of varied function into varied GPCR activation states Simulations were performed using 37 experimental structures of 11 Class A GPCR crystallized in multiple Median ligand RMSD values for top-scored poses were 1.2 Å and 2.0 Å for self-docking and StateMatch/FunctionMatch The distributions of ligand RMSD values were not statistically different for these two conditions, according estimated in advance based on docking target structure activation states, with higher accuracy expected when
- Dr. Nicola J. Smith - Dr. GPCR Podcast
GPCR Podcast, we have Dr. Subscribe to the podcast today and get notified when new episodes are released! Please share! https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #podcast
- Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
Here, we investigate the conformational changes induced by the binding of a nanobody (Nb80) on the active-like active-like conformation of the receptor, independent of ligand binding, in contrast to the conditions under which no intracellular binding partner is bound, in which case the receptor is only stabilized in an intermediate-active In particular, we identify unique allosteric signal transmission mechanisms between the Nb80-binding provide insights into the effect of intracellular binding partners on the GPCR activation mechanism, which