Search Results

authorization for the Company’s TAVNEOS (avacopan), an orally administered selective complement 5a receptor

axis, have entered a strategic research collaboration to identify and validate novel G protein-coupled receptor

CQ: chloroquine; E2F1: E2F transcription factor 1; FBS: fetal bovine serum; GPCRs: G protein-coupled receptors p62: sequestosome 1; STAT: signal transducer and activator of transcription; TACR1/NK1R: tachykinin receptor

September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-receptors

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in

recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein coupled receptors

ADX71149 is a selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulator

In conclusion, 10μM THC and CBD altered the differentiation of HC11 cells, in part via the CB2 receptor

of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, and a G protein-coupled receptor

β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs

specific LAT-1-positive neurons and first insights into the genetic network that is modulated by the receptor

crystallography, by cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors

in multiple immune signaling processes and is dependent on activation by Ras and G protein-coupled receptors

October 2022 "Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular

G protein-coupled receptor 3 (GPR3) belongs to the class A rhodopsin-type GPCR family and is highly expressed

Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors

The surface expression of pattern recognition receptors, such as TLR2 and TLR4, provides platelets with

September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein

We demonstrate that the chemoreceptor genes, srg-36 and srg-37, which encode G protein-coupled receptors

β-arrestin2 is a key protein that mediates desensitization and internalization of G protein-coupled receptors

The aim of this study was to identify Gα proteins mediating function of neuronal G protein-coupled receptors

Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates

BAI1 is expressed in the afferent spiral ganglion neurons in the mouse cochlea where it localizes AMPA receptors