endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating Endogenous ligands, named endocannabinoids, are produced “on demand” to finely regulate the synthesis and secretion of hormones and neurotransmitters, as well as to regulate the production of cytokines

Immunohistochemistry, western blot and quantitative real-time PCR techniques were used to analyze β2-AR protein and mRNA levels in a total of 65 histopathologically confirmed OSCC tissues (case group) and 65 normal

2022 Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling To assess the veracity of this claim, we compared endogenous KISS1R signalling and physiological output

Learn about communication between GPCRs and PKA, Class F GPCR Smoothened & the Hedgehog signaling pathway

Learn about his remarkable career and research in #GPCR signaling and trafficking.

Stuart Maudsley on how an aging physiological context affects #GPCR signaling #drgpcr.

Immunoblotting approach was used to analyze signaling involved in fentanyl’s action focusing on EGFR.

By targeting the receptors synaptically or non-synaptically, neurotransmitters activate multiple signaling

August 2022 "Abstract Sigma receptor is a transmembrane non-GPCR protein expressed mainly in the endoplasmic compounds showed more than 50% displacement of the radioligand at 10 µM concentration with compound 6c Moreover, compounds 6c and 6e showed a significant selectivity over S2R.

September 2022 Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key role in regulating

yesterday for contributions to the field of mass spectrometry and establishing it as method to analyse proteins

Previous findings suggest that parallel pathways independently relay innate threat signals from different

partner GlaxoSmithKline PLC posted results Dec. 7 demonstrating activity against the omicron spike protein

inhibition of glutamate release from presynaptic nerve terminals and is also poised upstream of a myriad of signaling

interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling

September 2022 "Research on cancer therapies focuses on processes such as angiogenesis, cell signaling

development approaches include a range of techniques leveraging structural biology, immunology, cell signaling

To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination

plan, the Danish giant will work with EraCal to identify novel drug targets relevant for food intake regulation

conducted to elucidate binding mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR protein

of monomeric β2-AR, unlike the inverse agonists, implying that the cholesterol is a specific factor regulating

We are closely monitoring any regulation changes from both Boston and Massachusetts with regard to in-person

causal role in eosinophilic CRS (ECRS) via macrophage IL‐1β overproduction, thereby suggesting autophagy regulation

Modulator Screening Platform Ad Hoc Announcement Pursuant to Art. 53 LR Geneva, Switzerland, April 6,

Major conformational differences were located on transmembrane (TM) 5 and 6, as well as intracellular

We identify 69 retinopathy variants, including 20 previously uncharacterized variants, that exhibit diminished Of these apparent class II variants, 67 exhibit a measurable increase in expression in the presence of

Orally bioavailable compound 47 with favorable agonist potency (Ca2+EC50 = 24 nM, cAMPi EC50 = 6.5 nM

institutional investor, pursuant to which the Company agreed to sell 3,752,202 shares in the form of 625,367 American Depositary Shares (“ADSs”) at a gross purchase price of $6.50 per ADS, which is equivalent The Unregistered Warrants have an exercise price of $6.50 per ADS, will become exercisable in 60 days The Unregistered Pre-Funded Warrants have been funded to the amount of $6.49 with $0.01 payable on exercise