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580 items found for "class A GPCR"
- C1-inhibitor influence on platelet activation by thrombin receptors agonists
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- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
September 2022 "The GPR15 receptor is a G protein-coupled receptor (GPCR), which is activated by an endogenous Read more at the source #DrGPCR #GPCR #IndustryNews
- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
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- Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
September 2022 "Given the promising clinical value of allosteric modulators of G protein-coupled-receptors (GPCRs ), mechanistic understanding of how these modulators alter GPCR function is of significance. Read more at the source #DrGPCR #GPCR #IndustryNews
- FSH and bone: Comparison between males with central versus primary hypogonadism
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- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
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- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies
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- A central alarm system that gates multi-sensory innate threat cues to the amygdala
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- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
September 2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate Serotonin1A receptors are important members of the GPCR family and are implicated in neuropsychiatric To explore the role of cholesterol in lateral dynamics of GPCRs, we utilized single particle tracking results bring out the interdependence of cholesterol and actin cytoskeleton in regulating diffusion of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
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- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
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- Interacting binding insights and conformational consequences of the differential activity of...
Notably, while CBD is able to antagonize some GPCRs in the endocannabinoid system, it also seems to activate we investigate the interacting determinants of CBD in two closely related endocannabinoid-activated GPCRs the CBD ligand in the GPR55 receptor elicit conformational changes associated with antagonist-bound GPCRs The all-atom MD simulations reveal that CBD induces conformational changes linked with agonist-bound GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
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- C3aR plays both sides in regulating resistance to bacterial infections
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- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
physiological functions in invertebrates through the interaction with G-protein-coupled receptors (GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
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- Identification of hub genes in the subacute spinal cord injury in rats
Finally, the relative mRNA expression level of central genes was verified by RT-PCR." Read more at the source #DrGPCR #GPCR #IndustryNews
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
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- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
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- Immunomodulatory Role of Neuropeptides in the Cornea
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- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
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- Addex Raises $10 Million In Equity Financing
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- Carola Weiss joins InterAx Biotech AG as VP Business Development
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- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
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- Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain
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- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
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- Oxford Professor Of Chemistry And Founder Of Therapeutic Company Wins Two International Awards
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- Sosei Heptares Announces Antitrust Clearance of License Agreement with Neurocrine Biosciences
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