Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in

ADX71149 is a selective metabotropic glutamate type 2 (mGlu2) receptor positive allosteric modulator

recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein coupled receptors

specific LAT-1-positive neurons and first insights into the genetic network that is modulated by the receptor

In conclusion, 10μM THC and CBD altered the differentiation of HC11 cells, in part via the CB2 receptor

of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, and a G protein-coupled receptor

crystallography, by cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors

Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors

The surface expression of pattern recognition receptors, such as TLR2 and TLR4, provides platelets with

, we investigated the role of chemical signaling in axon regeneration in Caenorhabditis elegans We find We demonstrate that the chemoreceptor genes, srg-36 and srg-37 , which encode G protein-coupled receptors

β-arrestin2 is a key protein that mediates desensitization and internalization of G protein-coupled receptors

linked to a spectrum of retinopathies that include retinitis pigmentosa and congenital stationary night blindness Evaluation of the observed shifts relative to thermodynamic estimates for the coupling between binding from computational modeling suggest that many of the least sensitive variants also directly compromise binding

The aim of this study was to identify Gα proteins mediating function of neuronal G protein-coupled receptors

Of course, there is the famous parade popularized by the James Bond movie Spectre. The Teotihuacan Pyramids: although it is very touristy, it is just a hop away from Mexico City and finds Don’t be surprised if you find yourself singing Daddy Yankee’s “Gasolina” from the top of your lungs BAI1 is expressed in the afferent spiral ganglion neurons in the mouse cochlea where it localizes AMPA receptors

Exendin-4, and possibly through G protein-coupled receptors (GPCRs), increases levels of cAMP and upregulates

migration of B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through binding These structures reveal an agonist binding site for the oxysterol and a potential ligand entrance site Mutations within the oxysterol binding site and the Gαi interface attenuate G protein signaling and abolish Together, these findings provide new insight into how EBI2 is activated by an oxysterol ligand and will

Our conversation provided additional insight you cannot find in a job description, so I thought I’d share Beth:  “We focus on biochemical, cell based, and radioligand binding assays to enable SAR, MOA, lead I keep an open door and you’ll find me among the team in the lab quite often.