GPCR Virtual Cafe session with Dr. Matthew E. on Friday, October 7th at 1 PM ET.

Here, we show that the gut IEL GLP-1 receptor (GLP-1R) is not required for enteroendocrine L cell GLP mediated by the suppression of gut IEL effector functions linked to the dampening of proximal T cell receptor signaling in a protein-kinase-A-dependent manner. Read more at the source #DrGPCR #GPCR #IndustryNews

Dopamine receptors are involved in the modulation of fundamental physiological functions, and dysregulation We demonstrate that azodopa activates D1-like receptors in vitro in a light-dependent manner. Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein In the absence of HH signaling, SMO is inhibited by Patched 1 (PTC1; a 12 pass transmembrane domain protein Read more at the source #DrGPCR #GPCR #IndustryNews

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of salivary adenoid cystic carcinoma via the PI3K/AKT signaling pathway "Background CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote Methods Immunohistochemistry staining and RT–qPCR analyses were performed to detect the correlation Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction Read more at the source #DrGPCR #GPCR #IndustryNews

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in Read more at the source #DrGPCR #GPCR #IndustryNews

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Tectonic Therapeutic , Inc. a pre-clinical stage biotechnology company transforming the discovery of novel GPCR-targeted therapies (G-Protein Coupled Receptors), today announced the promotion of Senior Vice President, Head Read more at the source #DrGPCR #GPCR #IndustryNews

"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in Crystal structures suggest ligand access to the orthosteric binding site of MT1 and MT2 receptors through entry route for 2-iodomelatonin, a nonselective agonist with a slower dissociation rate from the MT2 receptor which revealed different trajectories passing through the gap between TM helices IV and V for both receptors The side-chain flexibility of Tyr5.38 was significantly different in the two receptor subtypes, as assessed

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GPCR Ecosystem is under construction and dozens of your colleagues are enjoying its benefits! Catch up with the latest #GPCR news, start a discussion in the forum, and much more today! Join the #GPCR movement by becoming a site member for FREE! ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr

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In 2008 (and for the first time in the clinic), the therapeutic benefits of the β-adrenergic receptor Read more at the source #DrGPCR #GPCR #IndustryNews

GPR39 is a GPCR which can interact with Zn and modulate the colonocytes' survival. tumor-adjacent tissues by retrieving TCGA data and detected the expression of GPR39 in colon cancers with qPCR several other biomarkers including PPARG, EPCAM, and PD-L1 was investigated by re-analyzing TCGA data, qPCR Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Virtual Cafe? Register today! Addgene's Dr. Joanne Kamens is our guest. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe / #gpcr #drgpcr #virtualcafe #addgene

it contributes to pathophysiology, which is likely due to complex interactions among neuropeptides, receptor Read more at the source #DrGPCR #GPCR #IndustryNews

That precursor is inactive, but proteases from the coagulation and fibrinolytic cascades, as well as Chemerin can signal via two G protein-coupled receptors, chem1 and chem2, as well as be bound to a third non-signaling receptor, CCRL2. the specific tissue expression of the components of the chemerin system, and the role of different proteases Read more at the source #DrGPCR #GPCR #IndustryNews

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December 2021 "30/11/2021 Confo will work together with Regeneron to apply its GPCR drug discovery technology platform, which uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors) in disease-relevant conformations, will be applied with the goal of enabling the discovery of novel therapeutic antibody drug candidates. " Read more at the source #DrGPCR #GPCR

GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled Germline mutations in a G protein identify signaling cross-talk in T cells Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles GPCRs (FTY720) and desensitization of S1P1 receptor-mediated G-protein activation in a mouse model of sciatic Drug Discovery Flavors of GPCR signaling bias Glucagon-like peptide-1 receptor: mechanisms and advances

molecular docking was applied to valid the important interactions between the ingredients and the target protein herb-component-target" network indicated that the ingredients of Girinimbin, Gomisin B and Asarone, and the protein indicated that the mechanism of KXS in treating depression was involved in the biological process of GPCR HTR, DR, ADRA, AR, ESR, NR3C1) and modulate the activation of multiple pathways (Neuroactive ligand -receptor Read more at the source #DrGPCR #GPCR #IndustryNews

mechanosensation-dependent behavior in C. elegans via a trans function Latrophilins are highly conserved Adhesion GPCRs Recently, it has been shown that murine Latrophilins mediate classical G-protein signals to drive synaptogenesis This trans function is physiologically relevant in copulation behavior. specific LAT-1-positive neurons and first insights into the genetic network that is modulated by the receptor protein-mediated signaling.

GPCR podcast! 🥁 Drum rolls, please! Our guest is the wonderful Dr. Rosie Dawaliby! GPCR Ecosystem paid membership ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-84-with-rosie-dawaliby #gpcr #drgpcr

GPCR Summit from October 10th to the 16th is taking shape. GPCR Ecosystem site member, which is free! Sign up now ➡️ https://bit.ly/3eaO5PH #gpcr #drgpcr

GPCR Summit 2022. This is a great opportunity for us to come together and talk GPCRs. Join us now ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-summit-2022 #gpcr #drgpcr