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Glutamate exerts its effect through ionotropic and metabotropic glutamate receptors (mGluRs). mGluR2 drug targets for the treatment of many neurological conditions and several compounds targeting these receptors Read more at the source #DrGPCR #GPCR #IndustryNews

GPVI-Dependent Thrombus Formation under Shear "Glycoprotein (GP)VI and integrin αIIbβ3 are key signaling receptors Here, we focused on disclosing the integrin-dependent roles of focal adhesion kinase (protein tyrosine kinase 2, PTK2), the shear-dependent collagen receptor GPR56 (ADGRG1 gene), and calcium and integrin-binding protein 1 (CIB1). Read more at the source #DrGPCR #GPCR #IndustryNews

Mutations within the oxysterol binding site and the Gαi interface attenuate G protein signaling and abolish oxysterol-mediated cell migration indicating that G protein signaling directly involves in the oxysterol-EBI2 Read more at the source #DrGPCR #GPCR #IndustryNews

Abs against the angiotensin II receptor subtype 1 (AT1R) and the endothelin receptor type A (ETAR) are Promising nuclear receptors as key regulators of transcriptional programmes will be introduced as well Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Virtual Cafe session with Dr. Matthew E. on Friday, October 7th at 1 PM ET.

Here, we show that the gut IEL GLP-1 receptor (GLP-1R) is not required for enteroendocrine L cell GLP mediated by the suppression of gut IEL effector functions linked to the dampening of proximal T cell receptor signaling in a protein-kinase-A-dependent manner. Read more at the source #DrGPCR #GPCR #IndustryNews

Dopamine receptors are involved in the modulation of fundamental physiological functions, and dysregulation We demonstrate that azodopa activates D1-like receptors in vitro in a light-dependent manner. Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "The Smoothened receptor (SMO, a 7 pass transmembrane domain, Class F GPCR family protein In the absence of HH signaling, SMO is inhibited by Patched 1 (PTC1; a 12 pass transmembrane domain protein Read more at the source #DrGPCR #GPCR #IndustryNews

behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling pathway "Background CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote Methods Immunohistochemistry staining and RT–qPCR analyses were performed to detect the correlation of Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction Read more at the source #DrGPCR #GPCR #IndustryNews

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Tectonic Therapeutic, Inc. a pre-clinical stage biotechnology company transforming the discovery of novel GPCR-targeted therapies (G-Protein Coupled Receptors), today announced the promotion of Senior Vice President, Head Read more at the source #DrGPCR #GPCR #IndustryNews

"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in Crystal structures suggest ligand access to the orthosteric binding site of MT1 and MT2 receptors through entry route for 2-iodomelatonin, a nonselective agonist with a slower dissociation rate from the MT2 receptor which revealed different trajectories passing through the gap between TM helices IV and V for both receptors The side-chain flexibility of Tyr5.38 was significantly different in the two receptor subtypes, as assessed

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in Read more at the source #DrGPCR #GPCR #IndustryNews

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GPCR Ecosystem is under construction and dozens of your colleagues are enjoying its benefits! Catch up with the latest #GPCR news, start a discussion in the forum, and much more today! Join the #GPCR movement by becoming a site member for FREE! ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr

In 2008 (and for the first time in the clinic), the therapeutic benefits of the β-adrenergic receptor Read more at the source #DrGPCR #GPCR #IndustryNews

GPR39 is a GPCR which can interact with Zn and modulate the colonocytes' survival. tumor-adjacent tissues by retrieving TCGA data and detected the expression of GPR39 in colon cancers with qPCR several other biomarkers including PPARG, EPCAM, and PD-L1 was investigated by re-analyzing TCGA data, qPCR Read more at the source #DrGPCR #GPCR #IndustryNews

That precursor is inactive, but proteases from the coagulation and fibrinolytic cascades, as well as Chemerin can signal via two G protein-coupled receptors, chem1 and chem2, as well as be bound to a third non-signaling receptor, CCRL2. the specific tissue expression of the components of the chemerin system, and the role of different proteases Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Virtual Cafe? Register today! Addgene's Dr. Joanne Kamens is our guest. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe / #gpcr #drgpcr #virtualcafe #addgene

it contributes to pathophysiology, which is likely due to complex interactions among neuropeptides, receptor Read more at the source #DrGPCR #GPCR #IndustryNews

December 2021 "30/11/2021 Confo will work together with Regeneron to apply its GPCR drug discovery platform technology platform, which uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors) in disease-relevant conformations, will be applied with the goal of enabling the discovery of novel therapeutic antibody drug candidates. " Read more at the source #DrGPCR #GPCR

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