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559 items found for "Gorostiola González M"
- Platelets in the NETworks interweaving inflammation and thrombosis
Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release may directly engage pathogens and/or contribute to inflammatory signaling. massive neutrophil infiltration into the lung and NET formation. A better understanding of the underlying molecular mechanisms and the identification of treatment targets Read more at the source #DrGPCR #GPCR #IndustryNews
- Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
focused on the norepinephrine- α1-adrenoceptor signaling pathway and downstream signaling processes that mediate PLC activities self-regulate the expression of PLC isozymes with the suggestion that PLC activities may from the information provided, it is plausible that specific PLC isozymes could be targeted for the mitigation Read more at the source #DrGPCR #GPCR #IndustryNews
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
, and metabolic activity. an important molecular mechanism. We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1. its mitochondria-activating property." Read more at the source #DrGPCR #GPCR #IndustryNews
- Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
Background Fentanyl is an opioid analgesic and is widely used in ovarian cancer patients for pain management Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after Xenograft mouse model was generated to investigate the in vivo efficacy of fentanyl. Read more at the source #DrGPCR #GPCR #IndustryNews
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- Carola Weiss joins InterAx Biotech AG as VP Business Development
Carola Weiss is a Senior Executive with more than 20 years of international experience in the biopharmaceutical Carola Weiss ’ professional career brings deep expertise in business development, marketing & sales, licensing, alliance management, and strategic partnering. Read more at the source #DrGPCR #GPCR #IndustryNews
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline of Precision-Engineered Medicines improve clinical success Agreement to utilize Exscientia ’s AI-based capabilities and personalised medicine target identification through patient selection Research will be focused on up to 15 novel small molecule with the potential of $5.2 billion in total milestones plus tiered royalties PARIS & OXFORD, England Read more at the source #DrGPCR #GPCR #IndustryNews
- Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain
Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines Food and Drug Administration (FDA) that the study may proceed. TRV045 is the Company’s novel S1P1 receptor modulator being developed as a potential treatment for diabetic Read more at the source #DrGPCR #GPCR #IndustryNews
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
(p < 0.0001) as Measured by the Unified Huntington's Disease Rating Scale (UHDRS®) Total Maximal Chorea (TMC) Score- Placebo-Adjusted Mean Reduction in TMC Score of 3.2 Units in Valbenazine-Treated Patients The study met the primary endpoint of reduction in severity of chorea, the cardinal motor feature in Maximal Chorea (TMC) score from baseline to the average score at weeks 10 and 12 " Read more at the source #DrGPCR #GPCR #IndustryNews
- Sosei Heptares Announces Antitrust Clearance of License Agreement with Neurocrine Biosciences
License Agreement Neurocrine Biosciences has agreed to pay Sosei Heptares an upfront payment of US$100 million Read more at the source #DrGPCR #GPCR #IndustryNews
- Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
In this newly created role, she will focus on the application of artificial intelligence (AI), machine Professor Deane is one of the UK’s most accomplished bioinformaticians. She will maintain both of these roles, in addition to her role at Exscientia . played an active role during the COVID-19 pandemic as the UKRI’s COVID Response Director, and was a member R ead more at the source #DrGPCR #GPCR #IndustryNews
- Verily links up with Sosei Heptares for GPCR drug discovery
drugs in treating a range of health conditions, from cancer and genetic disorders to inflammation and metabolic Read more at the source #DrGPCR #GPCR #IndustryNews
- Septerna emerges with $100M to spark 'second golden age' of prolific drug target GPCR with ...
Better known as GPCR, the fruitful research space has led to more than 700 approved drugs over previous decades—but the two-year-old biotech believes the area is still ripe for development, and it now has $100 million The company's co-founder, GPCR pioneer and Nobel laureate Robert Lefkowitz , M.D., has 50 years of experience Read more at the source #DrGPCR #GPCR #IndustryNews
- InterAx Biotech AG and Boehringer Ingelheim take collaborate to unlock orphan targets leveraging ...
Collaborative efforts aim to accelerate and improve the prediction of first-in-class small molecule agonists systemsbiology #drugdiscovery #gpcr #deeptech #orphandrugs #pharma #partnerships #AI4drugdiscovery" Read more
- Ermium Therapeutics has constituted its SAB
leaders in GPCRs pharmacology, immunology, drug discovery and development for auto-immune diseases" Read more
- Research Network on Signal Transduction (ERNEST) has established an Emergency Fund for Ukrainian ...
March 2022 ERNEST has established an Emergency Fund for Ukrainian researchers. companies) Deadlines Start of the project: now End of the project: 31 October 2022 SHORT-TERM SCIENTIFIC MISSIONS (STSM) We offer short-term scientific mission grants to Ukrainian researchers who have been recently Read more at the source #DrGPCR #GPCR #IndustryNews
- ShouTi Introduces Basecamp Bio as a Wholly Owned Subsidiary to Expand Pipeline and Partnerships
March 2022 "February 17, 2022 08:00 AM Eastern Standard Time SAN FRANCISCO & SHANGHAI- ShouTi Inc., Read more at the source #DrGPCR #GPCR #IndustryNews
- Orion and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical ...
#ai #drugdiscovery #gpcr" Read more at the source #DrGPCR #GPCR #IndustryNews
- Inversago Pharma Completes Phase 1 Clinical Trial on First-in-Class, Peripheral CB1 Blocker and...
Blocker and Provides Strategy Update "Company has completed the Phase 1 Clinical Trial for its INV-202 molecule Phase 1 results and supportive preclinical package assist in the launch of Phase 2 clinical development Metabolic disorders are a global epidemic1 MONTREAL--(BUSINESS WIRE)--Inversago Pharma Inc. that focuses on treating metabolic disorder complications. Read more at the source #DrGPCR #GPCR #IndustryNews
- Drug Discovery Picks Up the Pace, Stays on Target
Such predicaments must have been familiar to the philosopher. He might reverse himself and declare that the perfect can in fact be the friend of the good. They include small molecules that conditionally modulate proteins in their functional state; three-dimensional (3D) cell models, or organoid models, that assist with target identification, high-throughput drug screening Read more at the source #DrGPCR #GPCR #IndustryNews
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
August 2022 "Despite the importance of members of the GPCR superfamily as targets of a broad range of effective medicines many GPCRs remain poorly characterised. Although blockade of GPR84 may potentially prove effective also in diseases associated with inflammation of the lower gut there is emerging interest in defining if agonists of GPR84 might find utility in conditions in which regulation of metabolism or energy sensing is compromised.
- Jan Steyaert Named 2022 Jacob and Louise Gabbay Award Winner
Belgium, has been named the winner of Brandeis’ 24th Jacob and Louise Gabbay Award in Biotechnology and Medicine Steyaert bridged fundamental high-impact research in biomedical sciences with the mechanistic understanding Read more at the source #DrGPCR #GPCR #IndustryNews