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575 items found for "G-protein coupled receptors (GPCRs)"
- Trainees, this is for you...
GPCR Summit 2022. Mark your calendar for October 10th and 16th. ➡️ https://www.ecosystem.drgpcr.com/ #gpcr #drgpcr
- Platelets in the NETworks interweaving inflammation and thrombosis
The surface expression of pattern recognition receptors, such as TLR2 and TLR4, provides platelets with Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release is characterized by neutrophils expelling chromatin fibres decorated with histones and antimicrobial proteins The negatively charged DNA within NETs provides a procoagulant surface, and in particular NET-derived proteins Read more at the source #DrGPCR #GPCR #IndustryNews
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
August 2022 "The apelin receptor (APJ) is a target for cardiovascular indications. pentan-3-yl)-1-cyclopentyl-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamide hydrochloride) of this GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Neurotransmitters: Potential Targets in Glioblastoma
By targeting the receptors synaptically or non-synaptically, neurotransmitters activate multiple signaling Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting Read more at the source #DrGPCR #GPCR #IndustryNews
- Let’s work better together!
➡️ https://bit.ly/3wQNZDg #gpcr #drgpcr
- A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine-vasopressin V2 receptor (V2R) and the only unique Kunitz-type peptide active on a GPCR. Read more at the source #DrGPCR #GPCR #IndustryNews
- Orion and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical ...
and precision-engineer therapeutics with enhanced potency and tailored signaling against an undrugged GPCR #ai #drugdiscovery #gpcr" Read more at the source #DrGPCR #GPCR #IndustryNews
- Trevena Announces Advancement of TRV045 Into Clinical Development for Diabetic Neuropathic Pain
TRV045 is the Company’s novel S1P1 receptor modulator being developed as a potential treatment for diabetic Read more at the source #DrGPCR #GPCR #IndustryNews
- C3aR plays both sides in regulating resistance to bacterial infections
results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor Read more at the source #DrGPCR #GPCR #IndustryNews
- Identification of hub genes in the subacute spinal cord injury in rats
correlation network analysis (WGCNA) were performed using R software, and functional enrichment analysis and protein–protein Finally, the relative mRNA expression level of central genes was verified by RT-PCR." Read more at the source #DrGPCR #GPCR #IndustryNews
- Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
will focus on the application of artificial intelligence (AI), machine learning, and the design of protein of Oxford , where she is currently Professor of Structural Bioinformatics and leads the University’s Protein R ead more at the source #DrGPCR #GPCR #IndustryNews
- Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
trisphosphate, which are downstream signal transducers for the expression of fetal genes, increased protein Read more at the source #DrGPCR #GPCR #IndustryNews
- Modulation of Striatal Adenosinergic Function by HTL0041178, a Selective GPR52 Agonist
novel GPR52 agonist HTL00411718 to modulate centrally mediated locomotor activity in response to A2A receptor control neuropsychiatric symptoms in conditions such as schizophrenia. " Read more at the source #DrGPCR #GPCR
- Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
Evaluation of the observed shifts relative to thermodynamic estimates for the coupling between binding Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE
- Addex Therapeutics Completes Patient Enrollment For Dipraglurant Blepharospasm Phase 2 Clinical ...
Dipraglurant selectively targets the metabotropic glutamate receptor subtype 5 (mGlu5) through allosteric Read more at the source #DrGPCR #GPCR #IndustryNews
- Addex Expands Pipeline With Selective M4 Positive Allosteric Modulator Program For The Treatment ...
drug discovery and development, announced today that it has moved a selective and potent M4 muscarinic receptor Read more at the source #DrGPCR #GPCR #IndustryNews
- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
Quantitative systems pharmacology (QSP) modeling is an emerging mechanistic computational approach that couples Read more at the source #DrGPCR #GPCR #IndustryNews
- Ermium Therapeutics has constituted its SAB
Therapeutics Announces the Formation of a Scientific Advisory Board comprising international leaders in GPCRs immunology, drug discovery and development for auto-immune diseases" Read more at the source #DrGPCR #GPCR
- Meet Peter McNamara, Ph.D., Tectonic’s SVP, Head of Research
Peter joined Tectonic to help chart new territory in GPCR science. Read more at the source #DrGPCR #GPCR #IndustryNews
- 4GPCRnet, September 26-29, 2022. Leipzig, Germany
August 2022 "WELCOME 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for Four of the biggest European networks on GPCR research (COST Actions Adher’n Rise and ERNEST plus DFG-funded Read more at the source #DrGPCR #GPCR #IndustryNews
- FSH and bone: Comparison between males with central versus primary hypogonadism
Read more at the source #DrGPCR #GPCR #IndustryNews
- Learn more about Neurocrine Biosciences with their new video
Read more at the source #DrGPCR #GPCR #IndustryNews
- Search for safer pain relief advances with new engineered compounds
pain-relieving compounds that, like morphine and other drugs, provide relief via activation of opioid receptors Read more at the source #DrGPCR #GPCR #IndustryNews
- ShouTi Introduces Basecamp Bio as a Wholly Owned Subsidiary to Expand Pipeline and Partnerships
Read more at the source #DrGPCR #GPCR #IndustryNews
- 2nd IRN i-GPCRnet, September 30 to October 1st, 2022. University of Wurzburg, Germany
Read more at the source #DrGPCR #GPCR #IndustryNews
- Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis by...
Read more at the source #DrGPCR #GPCR #IndustryNews
- California gold rush for Sosei Heptares
The vision is to develop novel muscarinic receptor agonists for schizophrenia and other neuropsychiatric Read more at the source #DrGPCR #GPCR #IndustryNews
- Carola Weiss joins InterAx Biotech AG as VP Business Development
Read more at the source #DrGPCR #GPCR #IndustryNews
