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580 items found for "Metabolite GPCR"
- Dr. Thomas P. Sakmar receives an honorary doctorate from Karolinska Institute
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- Addex's strategic partner The Janssen Pharmaceutical Companies of Johnson & Johnson, Inc. has...
potential global development of ADX71149 for the treatment of epilepsy. " Read more at the source #DrGPCR #GPCR
- Positive Recommendation for Use of TAVNEOS™ (avacopan) in ANCA Vasculitis Adopted by European ...
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- Trevena Adds Seasoned Biopharma Commercial Executive to Senior Leadership Team
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- Newly launched antibody libraries put hard-to-drug targets within reach
To target hard-to-drug targets like G protein-coupled receptors (GPCRs), more libraries, including better Read more at the source #DrGPCR #GPCR #IndustryNews
- Search for safer pain relief advances with new engineered compounds
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- Dr. Alexander S. Hauser receives the Bachem award for peptide science
November 2021 Read more at the source #DrGPCR #GPCR #IndustryNews
- California gold rush for Sosei Heptares
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- Neurocrine Biosciences Presents Data on Treatment of Adolescent Patients with Classic Congenital ...
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- Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...
regulation G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are their secretion of insulin, and islet function can be modified by ligands acting at the large number of GPCRs and, in this review, we have compared expression of GPCR mRNAs in human islets obtained from normal We have also considered the likely outcomes on islet function that the altered GPCR expression status confers and the possible impact that adipokines, secreted from expanded fat depots, could have at those GPCRs
- Exscientia welcomes Richard J. Law, as their new Chief Business Officer
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- InterAx Biotech AG and Boehringer Ingelheim take collaborate to unlock orphan targets leveraging ...
accelerate and improve the prediction of first-in-class small molecule agonists for a challenging orphan GPCR #ai #biotech #systemsbiology #drugdiscovery #gpcr #deeptech #orphandrugs #pharma #partnerships #AI4drugdiscovery " Read more at the source #DrGPCR #GPCR #IndustryNews
- Exscientia is 10 years old this July!
#artificialintelligence #drugdesign #drugdiscovery" Read more at the source #DrGPCR #GPCR #IndustryNews
- G protein-coupled receptors that influence lifespan of human and animal models
In this sense, G protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while In this way, we present the analysis of a series of GPCRs whose activity has been shown to affect the Our compilation of data revealed that the mechanisms most involved in the role of GPCRs in lifespan are possibility of using agonist or antagonist drugs, depending on the beneficial or harmful effects of each GPCR
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities that regulate a diverse array of biological functions. They recognize two types of G protein-coupled receptors (LPARs): LPA1-3 receptors and LPA4-6 receptors that belong to the endothelial gene (EDG) family and non-endothelial gene family, respectively. In recent years, the LPA signaling pathway has captured an increasing amount of attention because of its involvement in various diseases, such as idiopathic pulmonary fibrosis, cancers, cardiovascular diseases and neuropathic pain, making it a promising target for drug development. While no drugs targeting LPARs have been approved by the FDA thus far, at least three antagonists have entered phase Ⅱ clinical trials for idiopathic pulmonary fibrosis (BMS-986020 and BMS-986278) and systemic sclerosis (SAR100842), and one radioligand (BMT-136088/18F-BMS-986327) has entered phase Ⅰ clinical trials for positron emission tomography (PET) imaging of idiopathic pulmonary fibrosis. This article provides an extensive review on the current status of ligand development targeting LPA receptors to modulate LPA signaling and their therapeutic potential in various diseases. Read full article
- G protein-coupled receptor interactions and modification of signalling involving the ghrelin ...
extend to regulation of neurogenesis, learning and memory, gastrointestinal motility, glucose/lipid metabolism vitro and in vivo data suggest that GHSR1a heterodimerises with multiple G protein-coupled receptors (GPCRs This review discusses the signalling mechanisms of GHSR1a alone and in combination with other GPCRs, and explores the physiological consequences of GHSR1a coupling with other GPCRs.
- Functional molecular switches of mammalian G protein-coupled bitter-taste receptors
Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs Using current knowledge on class A GPCRs and existing experimental data in the literature as constraints
- Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent ...
mechanosensation-dependent behavior in C. elegans via a trans function Latrophilins are highly conserved Adhesion GPCRs
- AcroScreen co-founder Margaux Duchamp has been selected as a 30 under 30 Europe Forbes ranking 2022
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- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling G protein-coupled receptors (GPCRs Members of the Mas-related G protein coupled receptors (MRGPRs), a subfamily of GPCRs, are largely expressed
- Addex Therapeutics CEO Tim Dyer: There is a $4-bil market opportunity in dyskinesia
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- G.CLIPS biotech is 2 years old this month!
forward for more 🎊 #team #grateful #biotech #work #birthdaycelebration" Read more at the source #DrGPCR #GPCR
- Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled ...
structural positions in class A G protein-coupled receptors expressed in tumors G protein-coupled receptors (GPCRs Because there are many more GPCRs than effectors, mutations in different receptors could perturb signaling may not be enriched within a single gene but rather that cognate mutations with similar effects on GPCR To test this possibility, we systematically aggregated somatic cancer mutations across class A GPCRs The possibility that multiple different GPCRs could moonlight as drivers or enablers of a given cancer
- OMass Therapeutics's founder, Carol Robinson, has been awarded the prestigious Louis-Jeantet ...
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- Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
receptor-ligand complexes: Impact of ligand type and receptor activation state G protein-coupled receptors (GPCR Their abundance and role in nearly all physiological systems make GPCR the largest protein family targeted provided broadly generalizable performance expectations for docking into experimentally-characterized GPCR Simulations were performed using 37 experimental structures of 11 Class A GPCR crystallized in multiple Therefore, docking performance against GPCR targets can be estimated in advance based on docking target
- 📢 Early Bird Registration Ends Tomorrow! | Sep 16 - 22, 2024
Ahoy, GPCR Crew! GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and November 25 - 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug via p38-SCD1 axis Methods & Updates in GPCR Research GPCRSPACE: A New GPCR Real Expanded Library Based
- Profiling Immune Cell and Platelet Transcriptomes
G protein-coupled receptors (GPCRs) are integral to cellular signaling, influencing a wide array of physiological advancements in transcriptomic profiling have provided new insights into the expression patterns of GPCRs The study reports that human white blood cells express an average of 160 GPCR mRNAs, ranging from 123 to 206, while platelets exhibit a distinct profile with 69 GPCR mRNAs. abundant and rare GPCR transcripts.
- SYnAbs is now officially accredited as a Research Tax Credit by the French Ministry of Higher...
#technology #lifescience #immunology #antibodies #medicine #cancer #innovation #gpcr #synabs #monoclonalantibodies pharmaindustry #pharmaceuticals #oncology #healthcare #drugdevelopment" Read more at the source #DrGPCR #GPCR