Jean-Philippe Pin Jean-Philippe Pin participated in the discovery of metabotropic glutamate receptors been studying the allosteric modulation and activation mechanism of this family of G protein-coupled receptors His studies led to new concepts in the GPCR field, such as the activation of cell surface receptors by

graduate school at the University of California at Irvine, studying the regulation of ionotropic glutamate receptors , Oregon, to do a post-doctoral fellowship in the laboratory of Thomas Soderling studying glutamate receptor continued his post-doctoral training at Duke University, where he studied the regulation of adrenergic receptors contributions to understanding the signaling, regulation and in vivo actions of the neuroprotective receptors Randy’s lab has a special interest in studying disease-associated mutations to human GPCRs that perturb receptor

Today he and his team are working on understanding receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological settings with a special interest in His favorite GPCR is the angiotensin 1 receptor, especially for its ability to activate a large variety

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and I investigated the effect of lung cancer-related mutations in the GAIN domain of the Latrophilin 3 receptor

at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor

for the Treatment of Inflammatory Diseases Published date April 20, 2023 Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases

the development of approaches to quantify ligand bias and the identification of beta-arrestin-biased receptors The main focus of his lab’s research is on the mechanisms underlying biased agonism at chemokine receptors The chemokine system is relatively unique in having multiple receptors and multiple ligands that display His group and others have shown that many of these ligands act as biased agonists for the same receptor

Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

Structural Determinants Of GAIN Domain Autoproteolysis And Cleavage Resistance Of Adhesion G Protein-Coupled Receptors The GPCR autoproteolysis-inducing (GAIN) domain is a hallmark feature of adhe-sion G-protein coupled receptors We de-termined the crystal structure of the human ADGRB2/BAI2 hormone receptor (HormR) and GAIN domains domains which regulates signaling Sumit Bandekar Abstract "Cadherin EGF Laminin G seven-pass G-type receptors (CELSRs) are conserved adhesion G protein-coupled receptors; they are essential for embryogenesis and

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are

< GPCR News < GPCRs in Oncology and Immunology Activation of PI3K/Akt pathway by G protein-coupled receptor Among eukaryotes, the G protein-coupled receptor (GPCR) family stands as the largest group of membrane As a member of the GPCR family, G protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

One approach to treating patients suffering from lung cancer is to target surface receptors overexpressed on tumor cells, such as GPCR-family kinin receptors, and proteases that control tumor progression, such Considering the multiple functions of kinin receptors and KLKs, this review highlights their roles, even Villarroel-Espindola , Carlos D Figueroa , Pamela Ehrenfeld Tags KLKs , Kallikrein-related peptidases , Kinin receptors

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

The characterized compounds were evaluated on four G-protein coupled receptors (GPCRs: GPR35, muscarinic acetylcholine receptor M3, alpha-1A adrenergic receptor α1A and cannabinoid receptor CB2). Yumin Yao, Jixia Wang, Yanfang Liu, Xinmiao Liang Tags Benign prostatic hyperplasia , G-protein coupled receptor

RNA-seq Published date August 8, 2023 Abstract "Background: About one-third of patients with estrogen receptor alpha (ERα)-positive breast cancer have tumors which are progesterone receptor (PR) negative. seven significantly enriched biological processes affected by PR and associated with G protein-coupled receptor Rolf Jaggi Tags Breast cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen receptor alpha , gene expression , Progesterone receptor.

Oncology and Immunology Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors group of CC-chemokines are the macrophage inflammatory proteins (MIP), which are promiscuous for the receptors

signaling pathways and trafficking Localization of putative ligands for adhesion G protein-coupled receptors Yuling Feng The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr. These cleaved fragments join to form the heteromeric ADGRG6 receptor complex.

focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr.

Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the globally-recognized expertise in bioluminescence resonance energy transfer (BRET) technology, including his patented Receptor-Heteromer Investigation Technology (Receptor-HIT) for studying heteromers.

VII Physiological and pathological roles of AGPCRs in the nervous system Adhesion G protein-coupled receptor neuronal and neuroimmune alterations during neurodevelopment Mariam Melkumyan Adhesion G protein-coupled receptor The Notch Pathway To Control Germ Cell Proliferation Willem Berend Post Adhesion G protein-coupled receptor Mariam Melkumyan on the web LinkedIn Google Scholar Adhesion G protein-coupled receptor ADGRG1 promotes We found that the receptor is cleaved despite the lack of a consensus GPS sequence.

Chris de Graaf September 14, 2021 at 12:00:00 PM Learn More >> Designer G protein-coupled receptors as David Gloriam September 15, 2021 at 6:00:00 PM Learn More >> Hydroxycarboxylic acid receptor 3 and GPR84 Scott September 15, 2021 at 8:00:00 PM Learn More >> The challenges of targeting RXFP1, the receptor September 16, 2021 at 12:00:00 PM Learn More >> Phosphorylation of the M1 muscarinic acetylcholine receptor Ajay Yekkirala September 16, 2021 at 2:00:00 PM Learn More >> Chaperoning G protein-coupled receptors