of GPCRs in disease states to help test the feasibility of using protein-targeted degradation as a therapeutic

embody the multifaceted nature of GPCRs, showcasing their complexity, versatility, and potential for therapeutic

orphan GPCRs from ‘locked’, inaccessible receptors to well-characterized and understood ‘unlocked’ therapeutic

record as a biologics leader as he led teams to discover and develop novel first-in-class antibody therapeutics

vehicle by which Andrew is translating fundamental findings to commercial products is Keltic Pharma Therapeutics

Optimization of Candidate Molecules GPCRs have been and arguably still are the most prolific and fertile therapeutic

regulation, discuss its target proteins and mechanisms, and conjecture a rationale for developing ITA-based therapeutics

Session 4 - 3: 45 pm to 5:15 pm EST GPCRs in Immunology and Oncology November 17, 2023 Details GPCRs as Therapeutic

We hope our research will aid in the development of new therapeutic interventions for the alleviation

The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic

Institute of Medical Research, Deputy Director of the Australian Research Council Centre for Personalised Therapeutics

He is also an Associate Leader of the Experimental Therapeutics and Metabolism Program and the Director

signaling in the context of humoral immunity and discuss the potential of the COMMD3/8 complex as a therapeutic

Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994).

clinical stage company developing next generation immunotherapies, and member of the SAB of Domain Therapeutics

identification, polypharmacology, and effective personalized medicine approaches to achieve better therapeutic

Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994).

nanobodies as research tools, to investigate different GPCR conformations, while also focusing on their therapeutic

mechanisms of G-protein activation dysregulated in disease, these findings warrant the exploration of therapeutic

of Canada (2014), the Julie Axelrod award from the American Society of Pharmacology and Exerimental Therapeutics

Optimization of Candidate Molecules GPCRs have been and arguably still are the most prolific and fertile therapeutic

agonist enhances expression of GAL2 receptor, not only in PDAC-PDX but also in healthy tissue indicating therapeutic

receptors would be a significant breakthrough in cardiovascular biology as they could be targeted for therapeutic

interplay between CXCR4 and HRH1, and suggest the possibility of the CXCR4-HRH1 heteromer as a potential therapeutic

Yamina will schedule a future talk with Jacek about GPCRs as therapeutic modalities. The discussion revealed their interest in GPCRs as therapeutic modalities and possible future collaborations

Michael Feigin is an Associate Professor in the Department of Pharmacology and Therapeutics, and Director of Graduate Studies of Experimental Therapeutics at Roswell Park Comprehensive Cancer Center in Buffalo disrupting histone processing on rapidly proliferating cells, such as cancer cells, and suggested a therapeutic

drug action and is known for applying binding and signaling kinetics to the development of effective therapeutics

understanding the molecular basis for human tumor development and how to use this knowledge to devise new therapeutics Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic