Search Results
87 items found for "Brian K Shoichet"
- Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
K., Hoppe, N., Huang, X.-P., Macdonald, C. B., Mehrotra, E., Patrick Rockefeller Grimes, Zahm, A.
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
BERKY consists of a membrane linker, a BRET donor, an ER/K α-helix linker, a BRET acceptor, and an active
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
full control of signaling activity through a small protein GPCR via library-based screening Dorgham, K. candidate hits from library-based screening so that they can be tested in cell-based assays Akondi, K. small proteins show full in vivo efficacy in a highly stringent model of HIV transmission Steinbach, K.
- Adhesion GPCR Consortium Newsletter - May 2024
Bandekar with help from Nathan Zaidman and Abhishek K. Singh
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
accordance with our findings demonstrating the prevalence of 5-HT2A–TrkB heteroreceptor complexes in these brain especially the striatum, demonstrating that the balance between TrkB and 5-HT2A may shift in certain brain heterodimerization and suggest that the regulated expression of 5-HT2A and TrkB is a molecular mechanism for the brain-region-specific
- Glyco-sulfo hotspots in the chemokine receptor system
a single sialic acid, although, in rare cases glycans can carry polysialylation (PolySia) (Mindler K
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain innate threat cues are integrated and conveyed from each sensory modality to the amygdala, a critical brain
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
September 2022 "Glutamate is the primary excitatory neurotransmitter in the brain and plays critical orthosteric and allosteric ligands acting on either mGluR2, mGluR3 or both for the management of these brain
- Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging...
September 2022 Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain electrophysiological studies, indicate that CB2 receptors are expressed in specific dopaminergic and glutamatergic brain
- G-protein-coupled receptors as therapeutic targets for glioblastoma
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumour in adults. Despite this, the prognosis remains poor, with an impacted quality of life during treatment coupled with brain
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
discovery programs in key therapeutic areas Kallyope, pioneers in drug discovery involving the gut-brain biopharmaceutical company, and New York City-based Kallyope , pioneers in drug discovery involving the gut-brain
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
functions distinct from odor perception, and may contribute to the pathogenesis of disorders including brain Glioma is the most common adult malignant brain tumor and requires novel therapeutic strategies to improve Here, we outlined the expression of brain ORs and investigated OR expression levels in glioma.
- Diversity and specificity in location-based signaling outputs of neuronal GPCRs
by which members of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the brain
- Illuminating the draggable GPCR-ome
Bryan Roth There are 10 open tickets available. Get yours now!
- In Vitro and In Silico Characterization of Kurarinone as a Dopamine D 1A Receptor Antagonist and ...
Alterations in the expression and/or activity of brain G-protein-coupled receptors (GPCRs) such as dopamine Since studies have indicated that flavonoids can target brain GPCRs and provide neuroprotection via inhibition
- Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation
functional role of the astrocytic Gi pathway is not clear, as the literature is conflicting depending on the brain between enhanced calcium transients and the inflammatory phenotype of astrocytes observed in the inflamed brain
- AELIS PHARMA launches their IPO for €25 million
fundraising gives us the means to achieve our ambitions: to become a leading player in the field of brain
- Neurotransmitters: Potential Targets in Glioblastoma
September 2022 "For decades, glioblastoma multiforme (GBM), a type of the most lethal brain tumor, has
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
Exclusive access to private groups Over 30 recorded talks from Symposia - that's a lot of brain food To Design Novel GPCR- Targeted Antibody Therapeutics Using Generative AI Zombie Fungi Hijack Hosts’ Brains punctata GPCRs in Neuroscience Neuron specific quantitation of Gαolf expression and signaling in murine brain
- Emerging approaches for decoding neuropeptide transmission
in high-resolution techniques to investigate peptidergic transmission and expression throughout the brain
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
This compound has vastly reduced brain penetration and is devoid of significant off-target liability.
- Adenosine receptor signalling in Alzheimer's disease
The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in
- Adenosine receptor signalling in Alzheimer's disease
The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in
- Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
In other brain regions, astrocytes sense diverse neurotransmitters and neuromodulators and, in turn,
- The regulation of PKA signaling in obesity and in the maintenance of metabolic health
Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic
- Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology
Crinetics hires people with big brains and small egos.”
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal and blood-brain
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum