GPCR Activation and Signaling The dual-function chemokine receptor CCR2 drives migration and chemokine

Figure 3: In a single discovery campaign (CCR5 is shown as an example), Orion’s PROcisionXᵀᴹ platform Figure 4: Payload delivery using Orion’s superagonist analogs on target cells expressing CCR5. Case study: Discovering a CCR2 Antagonist The chemokine receptor CCR2 regulates the recruitment of monocytes Since many inflammatory diseases are driven by inappropriate recruitment of monocytes into tissues, CCR2 Orion’s CCR2 antagonist analog (OB-004), discovered in only 6 months, is considerably more potent than

Showcase in Tokyo, Japan, organized by LINK-J Jounce takes the cash under amended deal with Gilead on anti-CCR8

protein-coupled receptors, chem1 and chem2, as well as be bound to a third non-signaling receptor, CCRL2

Hartley will also present new data on Orion’s CCR2 antagonist, OB-004, demonstrating the ability of this