dendritic cells Published date October 29, 2024 Abstract "The intestinal lumen is rich in gut microbial metabolites G-protein-coupled receptors (GPCRs) sense metabolites and can act as key mediators that translate gut Here, we show that GPR31, which is activated by the gut bacterial metabolite pyruvate, is specifically Our results highlight the role of GPCRs in tuning the human gut immune system according to local metabolic

in Oncology and Immunology The power of many: Multilevel targeting of representative chemokine and metabolite This review offers a focused examination of selected protumorigenic chemokine and metabolite-sensing

Anderson , Raghavendra G Mirmira Tags G-protein coupled receptor (GPCR) , Macrophage , inflammation , metabolism

My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites research, I was part of a study that identified the receptors of a novel human gut microbe-derived metabolite discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction. identifying allosteric modulators of host G-protein-coupled receptors (GPCRs) that contribute to cardio-metabolic

Loss of Gpr101 on macrophages was also associated with a significant disruption in their cellular metabolism

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites To this end, we focused on analysis of bacterial metabolites that are currently recognized to bind to We further mapped the distribution of these molecules across the public mass spectrometry-based metabolomics from a public human protein atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human molecules across the druggable human GPCRome, a useful framework for integration of microbiome and metabolite

< GPCR News < GPCRs in Oncology and Immunology A disturbed metabolite-GPCR axis is associated with microbial Indeed, gut microbiota dysbiosis and metabolomic profile alterations, are hallmarks of IBD. In this scenario, metabolite-sensing G-protein coupled receptors (GPCRs), involved in several biological The aim of this study was to characterize the axis microbiota-metabolite-GPCR in intestinal surgical These patients also exhibited upregulated expression of most metabolite-sensing GPCRs analysed, which

< GPCR News < GPCRs in Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood System, and Western Diseases Published date November 20, 2023 Abstract "We show that the gut bacterial metabolites Likely, many other metabolites will be present at high concentrations. Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune

This acidification is the result of altered tumor metabolism favoring aerobic glycolysis, a phenomenon

that CD97 (ADGRE5), in particular, drives tumor growth via effects on GBM stem cell self-renewal and metabolism

Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic

Read More 9:50 AM Welcoming Remarks Read More 10:00 AM Student Flash Presentations Health and Disease, Metabolism

< GPCR News < GPCRs in Oncology and Immunology Metallo-protease Peptidase M84 from Bacillusaltitudinis This metallo-protease had no discernible impact on normal cell survival, but it specifically induced

Metabolic cage experiments demonstrated no differences in fluid intake, urine volume, urinary pH or urine

-25 Download PDF Program HERE < Back to Full Agenda Student Flash Presentations Health and Disease, Metabolism

Sandelin , Marie Kveiborg , Thue W Schwartz , Stine F Pedersen Tags EPHA7 , Extracellular matrix , HCAR1 , Metabolite