., Sinha, S., Silas, A. J., Ghassemian, M., Kufareva, I., & Ghosh, P. (2024).

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Since MOR receptor regulates pain perception and reward, the dysfunction in the MOR-SNARE complex interaction

GPCR dimers are very attractive molecular entities since they have been found to drive biased signalling

Signaling bias can be seen as complex as advantageous since selectively inhibiting certain signaling

However, opioids that prevent recruiting β-arrestin 2 do not address the problem since ligands that only

a structural perspective, the -4 position of αH5 was key for the selectivity of G-protein coupling, since

HEK293 cells, however there was only a minor loss in receptor internalization, which is surprising since

article on Profiling Immune Cell and Platelet Transcriptomes , and we want to wish her the best of luck leveraging GPCR expertise as a discovery engine - multiple partners have already signed on to the science Lundbeck

Photopharmacology GPCRs in Cardiology, Endocrinology, and Taste Rap1A Modulates Store-Operated Calcium Entry in the Lung

management, driving the obesity market toward $66 billion by 2030 and on track to become one of the most lucrative

Lukas Grätz , Jan Voss , and Gunnar Schulte , for their study on Class-Wide Analysis of Frizzled-Dishevelled

Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway Deciphering the genetic landscape of lumpy $4.6 Million in Milestone Payments from Centessa Pharmaceuticals CB1 receptor inverse agonist improves lung

FRET and BRET sensors operate on the principle of energy transfer between a fluorescent or luminescent Luttrell, and M.H. Lee, Probing Arrestin Function Using Intramolecular FlAsH-BRET Biosensors. 

This week's highlight includes congrats to: Luca Franchini and Cesare Orlandi for their research on Deorphanization

Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target Gunnar Schulte, Lukas

al. for their research on Time-resolved cryo-EM of G-protein activation by a GPCR Remi Janicot, Alex Luebbers

prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung

., Luttrell, L. M., & Lefkowitz, R. J. (2003).

elegan Species-Specific Duplicated FMRFaR-like Gene A62 Regulates Spontaneous Locomotion in Apolygus lucorum A Perspective on Class C GPCR Based Genetically Encoded Biosensors Emergence of lumpy skin disease virus

for FY2023 Financial Results Novartis Automates New Radioligand Therapy Production Plant Novartis’ Lutathera

nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction Industry News Novartis Lutathera

disorder GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung

neurosteroid concept to metabolomics: New insights into pregnenolone function Molecular characterization of lumpy

Since shape space exploration is specifically focused on the ‘message’ site in the TM domain, this means Since many inflammatory diseases are driven by inappropriate recruitment of monocytes into tissues, CCR2

for the Treatment of Insomnia OMass Therapeutics Releases First Protein Structures in PDB, Advances Lupus

human islets AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung

Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds