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63 items found for "Cancer"
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
Dysregulation of prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative repurposing statins as Ras oncogene inhibitors and the failure of using prenyltransferase inhibitors in cancer
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
Published date October 23, 2023 Abstract Glioblastoma multiforme (GBM) is one of the most aggressive cancers We used The Cancer Genome Atlas (TCGA) GBM genomic dataset to identify differentially expressed genes
- AGPCR 24 Session VIII
Institute for Diabetes and Cancer, Helmholtz Centre Munich, Germany, 2. " About Anastasia Georgiadi "Head of Junior Group Endocrine Pharmacology, Institute of Diabetes and Cancer Professional Background Since 2021 Group Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2018 - 2021 Project Team Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Munich 2015 - 2018 Postdoctoral fellow, Department of Adipose Tissue Biology, Institute for Diabetes and Cancer
- AGPCR 24 Session III
Sabbagh undertook post-doctoral fellowships at the Ontario Cancer Institute and the University of Toronto projects aimed on drug discovery of small molecules for the treatment of inflammatory disorders and cancer Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC the development of innovative treatments for a range of diseases, including psychiatric disorders and cancer
- Ep 58 with Dr. Juan José Fung
Scientist at GPCR Therapeutics, Inc , a drug discovery company focused on targeting GPCR heteromers in cancer
- Ep 75 with Vaithish Velazhahan
His undergraduate thesis work on studying the biochemical mechanisms of flavonoids in cancer using nuclear
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
Lorazepam, which has off target agonism of GPR68, is linked to worse clinical outcomes for a variety of cancers However, the role of tumor microenvironment acidification in GPR68 activation has not been assessed in cancer
- Ep 136 with Murat Tunaboylu & Ben Holland
After switching to biotech, Murat has built cell imaging software and lab robots to accelerate cancer
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple
- Distinct sub-cellular signal propagation as a component of functional selectivity
of Biochemistry and Molecular Medicine and the CEO of the Institute for Research in Immunology and Cancer
- Unveiling Non-Canonical Functions for Gαq Signaling Pathways
(GRK2), a known regulator of Gq-GPCR signaling in HNSCC tumor progression (International Journal of Cancer
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
kinases AKT and CHK1 and the transcriptional regulators cMYC and STAT3 and by increasing the abundance of cancerous
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Caron on the web UNC-Chapel Hill Department of Cell Biology and Physiology UNC Lineberger Comprehensive Cancer
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
genes are promising therapeutic targets and plausible new innovation avenues to combat IM resistance in cancer
- Ep 78 with Dr. Stuart Maudsley
At the MRC he developed novel prostate cancer therapeutics based upon his research into GPCR pluridimensional
- Ep 43 with Dr. Stuart Maudsley
At the MRC he developed novel prostate cancer therapeutics based upon his research into GPCR pluridimensional
- Ep 72 with Dr. Stuart Maudsley
At the MRC he developed novel prostate cancer therapeutics based upon his research into GPCR pluridimensional
- Ep 151 with Dr GPCR Board
control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation and cancer research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation, and cancer
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
Authors Chenshen Huang , Fengshuo Zhu , Hao Zhang , Ning Wang , Qi Huang Tags Cancer , Machine learning
- Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
Chuanyuan Wei , Jianying Gu Tags G protein-coupled receptors , Immunotherapy , Melanoma , Multi-omics , Pan-cancer
- Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody
of regenerating liver 3 (PRL3) is a specific tumor antigen overexpressed in a broad range of adult cancer
- Ep 60 with Dr. Josephine (Pina) Cardarelli
The company’s mission is to discover and develop highly effective cancer therapeutics by targeting heteromers
- AGPCR 24 Student Flash Presentations
Formation in Li-Fraumeni Syndrome Alex Torrelli-Diljohn Abstract "Li-Fraumeni syndrome (LFS) is a rare cancer El Merahbi Rabih, Herzig Stephan , Georgiadi A , Helmholtz Center Munich, Institute of Diabetes and Cancer Vasiliki Karagiannakou "MSc in Bioinformatics, PhD student since 2022 in the Institute for Diabetes and Cancer Research Group to identify novel prognostic biomarkers and therapeutic options for Metastatic Breast Cancer
- GPCR Retreat 2023 | Dr. GPCR Ecosystem
world-class and diverse GPCR scientists working in the arenas of structure and signaling, neuroscience, cancer
- Ep 50 with Dr. Thomas P. Sakmar
and Ping Chi , that a mutant of CYSLTR2 is a driver oncogene in uveal melanoma, the most common eye cancer
- Ep 144 with Dr Aurélien Rizk
Cell Signaling and Cancer Metastasis Discussion Aurelien Rizk and Yamina Berchiche had a detailed conversation fascination of understanding how cells respond to gradients and signals, particularly in relation to cancer
- AGPCR 24 Session IV
of Medicine, where he studies BAI1's role in the brain and the radiobiology of treatments for brain cancer
- Ep 150 with Dr GPCR Team
During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the