Modern drug development approaches include a range of techniques leveraging structural biology, immunology

fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging

diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges

fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range

Wang, F., X. Chen, X. Zhang, and L. Ma. 2008.

fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging

We show that besides classical hydrogen bonds, weak polar interactions such as O-HC, O-Br, and long-range

Nevertheless, the GloSensor™ cAMP assay can be applied to analyze signaling by a wide range of GPCRs

Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with desensitization), the same drug acting on the same receptor in the same cellular context can produce a range

Coupled with their ability to respond to a highly diverse range of chemical stimuli, they represent the

significance of GPR39 was evaluated by analyzing the correlations with clinicopathological factors with the chi-square

., Wang, J.K., Bauer, B., Townshend, R.J.L., Hollingsworth, S.A., Olivieri, J.E., Xu, H.E., Sommer, M.E

Chemical communication controls a wide range of behaviors via conserved signaling networks.

Consequently, the dynamic range for IL-6 detection as an assay for β-alanine-mediated activation of MRGPRD

., Wang, N., Xu, Z., Xia, R., Liang, J., Duan, Y., Yin, H., Xiong, Y., Zhang, A., Guo, C., Chen, Z.,

Wang et al. 2009; R. J.

., Wang, B., Bouley, R., Potts, J. T., Gardella, T. J., & Vilardaga, J. P. (2009).

Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the range of

could unveil new dimensions of GPCR functionality and offer innovative approaches to treating a wide range

However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and There are approximately 800 human GPCRs in the superfamily, controlling a broad range of physiological Orion’s receptor antagonist analogs have demonstrated powerful efficacies across a range of animal models

The completion of the Human Genome Project revealed that GPCR genes in the human genome range from approximately

“ A substitution of one amino acid by another in a protein can have effects ranging from negligible to

Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1 Tongue-on-a-Chip

efficacy and potency in GPCR signaling Activation and characterization of G protein-coupled receptors for CHHs

activation will pave the way for significant advancements in the development of therapeutics for a wide range