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SMOOTHENED-PKA signaling in the Hedgehog cascade Elita Yuliantie , Arthur Christopoulos , Patrick M.

M., & Lefkowitz, R. J. (2003).

Continuing Study Addex Therapeutics in the 23rd BioEquity Europe Conference Simon Bekker-Jensen and Mette M

This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka,

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic

Anson, M., et al., Incidence of new onset type 2 diabetes in adults living with obesity treated with

Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on

Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in

Non-Peptide Small Molecule GLP-1 Receptor Agonist GSBR-1290 Crinetics Pharmaceuticals Appoints Robert M.

Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric

Maziarz, M., et al., Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor

insights into G protein coupling specificity at a class A GPCR Jianjun Cao, Arthur Christopoulos, Patrick M.

Burger , Arthur Christopoulos , David M.

genito-urinary system, the activation of ORs was shown to influence the motility of spermatozoa (Spehr M.

highlighted a new hydrophobic conserved motif composed of phenylalanine (F)/leucine (L) and methionine (M)

receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest to treat pain Pain may associate with inflamed tissue characterized by acidic pH. The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding

has pro-nociceptive properties, suggesting that blockade of Gq/11 signalling could be beneficial for pain Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice to painful

Dysregulation of RGS proteins has been implicated in a range of diseases, including cardiovascular disease, pain Relating to pain, RGS4 in pain regulation is a topic of increasing interest because it has been identified G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.

Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated Antinociception "Pain The current frontline approach for pain-management is the use of opioid analgesics.

Opioids are analgesic drugs consumed non-medically for euphoric feelings and medically for pain relief most important in regulating the response to nociception, i.e. the response of the nervous system to painful Given their pathophysiological significance in pain, addiction and depression opioid receptors represent Morphine is one of the most widely used and proven analgesic for the treatment of severe acute or chronic pain Complex Persistent Opioid Dependence-an Opioid-induced Chronic Pain Syndrome.

Shampo, M. A. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. Ekaterini Tiligada, C., Tiligada, E. & Ennis, M.

of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain

EGFR "Background Fentanyl is an opioid analgesic and is widely used in ovarian cancer patients for pain

preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases, pain

preclinical data support the applicability of CB2 activation in autoimmune and inflammatory diseases, pain

rights to develop certain retained compounds for Charcot-Marie-Tooth type 1A neuropathy (CMT1A) and pain

drawback of causing damage to healthy cells in the process, leading to side effects that can include pain

molecular dynamic simulations "The δ-opioid receptor (DOR) is a critical pharmaceutical target for pain