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with Elevated ß2-Adrenergic Receptor Autoantibodies-An Interim Report Published date October 9, 2023 Abstract There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic Encephalomyelitis/Chronic Anne Krüger , Markus Tölle , Carmen Scheibenbogen Tags GPCR-antibodies , Myalgic Encephalomyelitis/Chronic

Indian Institute of Science, Bangalore, India, to investigate the mechanisms behind rare mitochondrial diseases at the Cleveland Clinic in Ohio, USA, studying the gut microbiome and its impact on cardiovascular disease gut microbe-derived metabolite called phenylacetylglutamine (PAG), which is linked to cardiovascular disease as targets for more than one-third of all prescribed drugs currently used in the treatment of human diseases

receptors related to autoimmunity in postural orthostatic tachycardia syndrome Published date June 20, 2024 Abstract In particular, the association of the disease with several types of anti-G protein-coupled receptor ( To date, POTS is recognized as one of the sequelae of coronavirus disease 2019 (COVID-19) and its frequency

ABSTRACT SUBMISSION Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Submit your Abstract Here Abstracts configuration 1. Abstract category (oral presentations) 2. Title: Capitalize each word, 20 words max, Bold 3. Abstract body 6. Structure and Bioinformatics Health and Disease Immunology Nervous system Model Organism Phylogenetics

α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis Published date May 21, 2024 Abstract "Inflammatory bowel disease (IBD) is characterized by dysbiosis of the gut microbiota and dysfunction Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs , colitis , inflammatory bowel disease

characteristics of microenvironment and process of EBV-induced lymphomagenesis Published date November 15, 2023 Abstract However, the underlying mechanism of virus-cancer immunological interaction during disease pathogenesis comprehensive proteogenomic characterization of natural killer/T-cell lymphoma (NKTCL), a representative disease

colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21, 2024 Abstract elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors exhibited decreased disease-specific survival (DSS) and disease-free survival (DFS) compared to those with low RGS16 expression.

: RAMP-interacting GPCR Pathways Date & Time Thursday, November 2nd / 4:30 PM Keynote Talk Abstract Coming laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for metabolic diseases Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory diseases

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease , obesity, diabetes, chronic pain and addiction. Lastly, they discussed the progress of new drugs targeting specific receptors for various diseases, with

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease , obesity, diabetes, chronic pain and addiction. Lastly, they discussed the progress of new drugs targeting specific receptors for various diseases, with

curated the major advances in understanding GPCR biology and moving closer to targeting receptors in diseases

CXCR6: Convergent substitutions and recurrent gene loss in sauropsids Published date October 14, 2024 Abstract This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. CXCR6 in chickens may have altered CD8 TRM cell abundance, with implications for immunity against viral diseases

human T cells by directing GPCR and lipid second messenger signaling Published date November 11, 2023 Abstract directed migration (also referred to as chemotaxis) is a common pathogenic mechanism of inflammatory diseases have implications for therapeutically targeting TIPE proteins in human inflammatory and autoimmune diseases

Salinas The NTF Release Sensor Approach for Drug Discovery for Human Adhesion GPCRs Stephanie Häfner Abstract the identification of drugs targeting the unique aGPCR receptor family and customize the method for disease-relevant recruited by Vertex Pharmaceuticals (Canada) where he worked on biomarker discovery for inflammatory bowel disease and small molecules drug discovery for polycystic kidney disease. novel pharmacological targets and contribute to the development of innovative treatments for a range of diseases

research laboratory of around 15 staff supported by basic research grants investigating aspects of disease biology and the action of drugs in the context of disease.

of studying metabolites and their receptors, the relationship between metabolites, gut health, and disease They briefly touched upon the link between GPCRs and diseases, such as diabetes, but did not delve into Metabolites, Gut Health, and Disease Progression Yamina and Claudia had a discussion about the relationship between metabolites, gut health, and disease progression. Both agreed on the complexity of the topic, with Claudia concluding that diseases might first affect

inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration Published date September 25, 2023 Abstract findings propose a therapeutic potential in combined CXCR4 and LPA1 inhibitors for cancer and inflammatory diseases Video Abstract." receptor 4 , Chemotaxis , G protein-coupled receptor , GPCR heteromer , GPCR signaling , Inflammatory disease

A journey from Duke to McGill along the dopamine circuit Date & Time Friday, November 3rd / 8:55 AM Abstract McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to chronic

Signaling Confers Therapeutic Vulnerability in Ovarian Cancer Date & Time Friday, November 3rd / 3:55 PM Abstract This approach has provided insight into novel drivers resulting from the widespread gene copy number second area of interest has been the elucidation of the molecular basis for a rare autosomal human disease

laboratory has gained valuable insights into the genetic basis and pathophysiology of lymphatic vascular disease , preeclampsia and sex-dependent cardiovascular disease.

the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease investigating the role of metabotropic glutamate receptor signaling in Huntington’s and Alzheimer’s disease

and obtained a PhD in Molecular Medicine and a Clinical Specialisation in Endocrinology and Metabolic Disease protein-coupled receptor (GPCR) signalling and their alterations in endocrine, metabolic and cardiovascular diseases

gained experience in the identification and characterization of llama-derived antibodies in inflammatory diseases conformations, while also focusing on their therapeutic potential in oncology and transplant infectious disease

the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease investigating the role of metabotropic glutamate receptor signaling in Huntington’s and Alzheimer’s disease