inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling effects of NPY1R and NPY5R antagonists in normoxia and hypoxia on migration, proliferation, invasion, and signaling Antagonizing NPY1R and/or NPY5R in hypoxia compared to normoxia more greatly reduced MAPK signaling, oxygen availability, therefore further investigations are required to dissect the intricacies of NPYR signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

and Immunology NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling Our results also showed that ERK1/2 signaling was activated in SKOV3 cells in response to the NPFF treatment In addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression NPFF stimulates EOC cell invasion by upregulating MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

-25 Download PDF Program HERE < Back to Full Agenda Session IX / Technology capsule: Light on aGPCR signaling

< GPCR News < GPCRs in Oncology and Immunology DANGER Signals Activate G-Protein Receptor Kinases Suppressing Background: Injury mobilizes primitive 'DANGER signals' (DAMPs) activating innate immunocyte (neutrophils , PMN) signaling and function. Methods: We studied human and mouse PMN signaling elicited by mtDAMPs (GPCR surface expression; protein in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Immunology Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling Enhanced calcium signaling and cell migration are also observed in NCI-H23 and HeLa cells, which coexpress in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Immunology Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling resonance for glycosaminoglycan (GAG) binding affinity, assays for cell migration, second messenger signaling Moreover, CXCL10(1-73) exhibited an attenuated capacity to induce CXCR3A-mediated signaling, as evidenced in calcium mobilization assays and through quantification of phosphorylated extracellular signal-regulated : Our study shows that the C-terminal residues Lys74-Pro77 of CXCL10 are important for GAG binding, signaling

GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal This autoimmune loop in psoriasis pathogenesis is influenced by G protein-coupled receptor (GPCR) signalling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling Regulator of G protein signaling 20 (RGS20) is identified as an upregulated factor in many cancers, yet Western blotting demonstrated different expressions of autophagy and the Hippo-PKA signal pathway. Transcriptomic sequencing suggested the involvement of the Hippo signaling pathway in the action of RGS20 Remarkably, inhibiting Hippo signaling with GA-017 promoted cell proliferation and activated autophagy

< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal , Inflammation , Regulator of G protein signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

News < GPCRs in Oncology and Immunology Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling KS-133 in the presence of VIP decreased the phosphorylation of extracellular signal-regulated kinase Our findings suggest that VIPR2 signaling regulates cyclin D1 levels through the cAMP/PKA/ERK and PI3K in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent This study investigated the sphingosine-1-phosphate (S1P) signaling-associated genes (SphK1 and S1PRs Their network analysis uncovered significant clusters, emphasizing the interconnectedness of the S1P signaling Moreover, the S1P signaling genes are promising therapeutic targets and plausible new innovation avenues in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling by acting as negative regulators and tolerant RGS14-S127P and RGS10-S64T resulted in a loss-of-function phenotype in GPCR-G protein signaling overlap with cancer-linked mutations cause phenotypic changes that negatively impact GPCR-G protein signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Immunology miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling found that each cell type could be characterized by a unique expression profile of ion channels, GPCR signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling