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37 items found for "Debbie L. Hay"
- Finding needles in haystacks: Omass unveils pipeline aimed at tough-to-drug targets
November 2021 "Nov. 15, 2021 LONDON – There’s not yet proof of the pudding, but Omass Therapeutics Ltd.’s new structure-based technology has passed a key test, in enabling the discovery of orally available small molecules aimed at intractable and poorly drugged membrane and complex-bound protein targets. The targets, including G protein-coupled receptors (GPCRs), intracellular protein complexes and solute carriers, are relevant to immunology indications and rare diseases with high unmet need." Read more at the source #DrGPCR #GPCR #IndustryNews
- 📰 GPCR Weekly News, March 27 to April 4, 2023
Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced
- Odorant receptors – a bit of smell for drug discovery
In the skin, OR51E2 was shown to play a role in human melanocyte homeostasis (Gelis L. et. al 2016) and
- Overview of adhesion GPCRs self-activation
was performed highlighted a new hydrophobic conserved motif composed of phenylalanine (F)/leucine (L)
- Structural landscape of the Chemokine Receptor system
CXC chemokines with shallow binding near TM5, and CX3C chemokines with shallow binding near the ECL2 hairpin
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
September 2022 "Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
damage to healthy cells in the process, leading to side effects that can include pain, nausea, and hair