📢 Did you know that this 3rd Edition of the Dr.

☕ We are excited to announce our rescheduled Dr. GPCR Virtual Cafe session with Dr.

🌟The Dr. GPCR event of the year is the 3rd edition of the Summit. Become a Dr. GPCR Ecosystem site member to attend the Summit, it’s free!

 for their research on Advances in yeast synthetic biology for human GPCR biology and pharmacology Dr Unlock a 25% exclusive discount on these courses with Dr. Courses Schedule and  Benefits Every Thursday at 10 am EST Online Lectures 1:1 meeting with Dr. Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research Associate Join Dr

⚠️Mark your calendar for the Dr. GPCR Summit 2022 held between Oct. 10 - 16, it's FREE!

📅 Our FREE Dr. GPCR Summit 2022 is less than a month away!

July 2022 "I’m happy to share that I’m starting a new position as Scientific co-founder LASEREDD Therapeutics " Ross Bathgate Read more at the source #DrGPCR #GPCR #IndustryNews

Tomorrow is the day for another Dr. GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

June 2022 "We’re delighted to welcome Dr Ed Brennan as our new Vice President, Head of Clinical Development Dr Brennan has extensive experience across all phases of clinical development, and across multiple therapeutic

November 2021 Read more at the source #DrGPCR #GPCR #IndustryNews

Excited to hear Dr. Register here (FREE) https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe #drgpcr #gpcr #virtualcafe

Excited to hear Dr. automated micro-plate-based methods for quantifying #GPCR activation. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe

Come attend this month's virtual café talk to see the awesome work of Dr. Register here (FREE) https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

Join us and learn how to quantify your kinetic GPCR signaling from the expert himself: Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

November 2021 "So proud and grateful to receive honorary doctorate yesterday from Karolinska Institute and celebrate with my family in Stockholm." Read more at the source #DrGPCR #GPCR #IndustryNews

Did you register for our next Dr. GPCR Virtual Cafe? Register today! Addgene's Dr. research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe

Join us for the first virtual cafe talk to hear about the amazing work that Dr. Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

April 2022 Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes compared to morphine, exhibits inhibitory effect, and is used to treat opioid abuse. The mechanism by which the MOR distinguishes between the two is unclear. Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling are used here to determine the different interactions of these two ligands with MOR: morphine adjusted its pose by continuously flipping deeper into the pocket, whereas naloxone failed to penetrate deeper because its allyl group conflicts with several residues of MOR. The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes during the MD simulations. To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination with mutagenesis and electrophysiological recordings. We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified the key residue I322, which leads to differential recognition of morphine and naloxone while assisting EM-1 in activating MOR. Reducing the side chain size of I322 (MORI322A) transformed naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency of MOR on EM-1, confirming that binding deep in the pocket is critical for the agonistic effect of MOR. This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level." Read more at the source #DrGPCR #GPCR #IndustryNews

Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli ,   Albert J Kooistra ,   David E Gloriam ,   Alexander S Hauser GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli ,   Albert J Kooistra , Gáspár Pándy-Szekeres ,   David E Gloriam , et al. Direct line to the Dr.

This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on Join our upcoming Dr. GPCR University hands-on workshop with Dr.  The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Dr. Dr.

Dr. Drs. Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds In case you missed it, recordings of the Dr. Robert Lefkowitz Lab Postdoc Fellow - Dr.

Greetings, avid readers! Drs. Dr. GPCR University The past two weeks of the Dr. Dr. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr.

reveals unexpected differences in downstream pathway activation Chiara D Mancinelli , Joshua Levitz , David protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains Dr We are pleased to announce the scheduled dates for our highly anticipated courses led by Dr. Scientist; Biochemistry, Cellular and Mechanistic Pharmacology; Lead Discovery and Optimization   Join the Dr

Today, we celebrate a huge milestone by releasing Episode #150 of the Dr. GPCR Podcast. ’s episode, so join us in this celebration and be the first to know about all the changes coming to Dr Today is also the first session of our hands-on workshop with Dr. Sam Hoare. If you aren't joining us this time, stay tuned for more Dr. GPCR University content coming soon.

This week's highlight: Dr. Dr. GPCR University February 8 - 29: Join Dr. GPCR University's live course with Dr. Terry Kenakin. GPCR Ecosystem group, where you can find Dr. Kenakin and Dr. GPCR Complimentary one-year Dr. Go to Dr. GPCR University and save your spot today! Dr.

This week's highlight includes congrats to: Drs. Dr. GPCR Podcast Episode #151 is out! A special episode with our board, meet Drs. Did you watch Episode #150 of the Dr. GPCR Podcast? Dr. Dr.

This week's highlight: Dr.  Dr. GPCR University Our first Dr. Kenakin Access to the cohort’s Dr. Kenakin and Dr. GPCR Complimentary one-year Dr. Dr.