Principles of Pharmacology II $ 675 675$ +$20.25 Transaction fee Advanced Methods for the Optimization

10:00 AM Student Flash Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics Kordon Conformational And Functional Coupling Between Extracellular and Transmembrane Regions of a Holo-Adhesion for Brain Cancer Therapy Hailey Steichen Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript and TA-independent Mechanism of aGPCR Activation: Direct Communication of Extracellular Region with Transmembrane

Berchiche obtained her Master’s and Ph.D. in Biochemistry at the University of Montreal in Canada before training studying structure/function relationships of GPCRs using live-cell bioluminescence resonance energy transfer

addition, I generated various optical biosensors based on fluorescence or bioluminescence resonance energy transfer

1:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

8:00 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration

They also explored the significance of translating fundamental discoveries into clinical applications Summary Arthur's Career Journey and Transition to Dean Yamina introduced Arthur to her team and discussed Collaborative Research and Translational Approach Arthur and Yamina from Monash University discussed approach to research and its capacity to translate research into therapeutic commercialization. Translating Discovery Into Clinical Application Arthur and Yamina discussed the importance of translating

In the hedgehog pathway, bifunctional GLI transcription factors generate both GLI-activators (GLI-A) Ankmy2 mutants, and Gli2/Gli3 knockouts, Gli3R knock-in and knockout of Smoothened, the hedgehog pathway transducer

Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

He then moved to Thomas Jefferson University in Philadelphia, PA, for his postdoctoral training in Jeff the mechanisms that govern spatial and temporal regulation of GPCR signaling by -arrestins and post-translational

Bone marrow (BM) samples were collected at baseline for genomic and transcriptomic analysis (n = 32).

Using a transcriptomic analysis of over 37,000 nuclei, we identified twelve distinct clusters of cells

His group studies the unusual signaling mechanisms employed by these atypical 7-transmembrane receptors

during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic

Angers is an expert in the field of signal transduction. His thesis work led to the development and application of light energy transfer methodology to study protein-protein interaction and signal transduction. He is the recipient of the Canada Research Chair in Functional Architecture of Signal Transduction.

4:00 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

GPRC5D forms a symmetric homodimer with the interface between transmembrane helix (TM) 4 of one protomer

Gainetdinov is the Institute of Translational Biomedicine Director at Saint Petersburg State University

5:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

pH-GPCR) GPR4, are considered as potential initiators of the signaling cascades relevant to malignant transformation

study provides insights into addressing the challenges posed by CRC, offering avenues for clinical translation

investigate different GPCR conformations, while also focusing on their therapeutic potential in oncology and transplant Universiteit Brussel in the In Vivo Cellular and Molecular Imaging (ICMI) group that is focused on translational combine his previous GPCR experience with his current focus to set up his own research line focusing on translational

Medulloblastomas Virginea de Araujo Farias Conformational And Functional Coupling Between Extracellular and Transmembrane During my graduate studies, using various transgenic mouse models and expertise in intestinal and renal Since staring my postdoctoral training, I have continued to develop my expertise to answer fundamental However, how the ECR communicates with the seven-pass transmembrane domain (7TM) remains elusive, because Mariam started her postdoctoral training in February 2024 and is hoping to become an academic professor

After finishing her graduate training, she joined Dr. since the year 2000, the field has seen significant growth, with important discoveries such as the transmembrane

mutant cycle analysis , protein expression , protein-protein interaction , receptor binding , signal transduction