Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, in vitro: A potential antagonist of corticotropin-releasing Binders, Drugs, and more Altered signaling at the PTH receptor via modified agonist contacts with the extracellular

., for their research on Intracellular pocket conformations, determine signaling through the μ opioid autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage Intracellular Cardiology, Endocrinology, and Taste Dissecting a Brake for Airway Smooth Muscle Cell Movement Hepatic extracellular

Hébert and their colleagues research on 'G Protein-Biased Agonists for Intracellular Angiotensin Receptors GPCR Activation and Signaling G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote QTY variants Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular

Structurally they characterize by a long extracellular region of adhesion-like domains which modulate in their self-activating state, i.e. a unique activation model of aGPCRs where in the absence of the extracellular self-activation as well the selectivity of G-protein coupling using a mouse ADGRL3 receptor without extracellular peptide of ADGRL3 adopts a hook conformation when binds to the binding pocket formed by TM1-3,5-7 and extracellular

predicted models and experimental structures were different in many aspects including the assembly of the extracellular

Structurally, the extensive extracellular domain, which contains the hormone-binding site and is linked

Ca2+]i elevation and voltage-dependent current generated by MRGPRB2 activation were correlated with extracellular

Further, we describe dopamine-triggered regulation of extracellular ATP at PFC astrocyte territories.

The localization of GPCRs to specific intracellular compartments dictates the spatial and temporal dynamics For example, the lipid composition of intracellular membranes may influence GPCR dynamics and signaling Compartmentalized GPCR Signaling from Intracellular Membranes. Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5.

identified key conserved amino acids for GPR116 activation in the tethered agonist sequence and in extracellular

Endosomal signaling is critical for biased activation of G proteins, β-arrestins, and extracellular-signal-regulated

and extracellular loop regions that form the intracellular and extracellular faces of the receptor. These interactions induce local conformational changes which are amplified and transmitted to the intracellular protein GPCRs feature a two-component binding mechanism in which one part of the ligand engages the extracellular Left: Natural ligands of small protein GPCRs use a two-component binding mechanism, with extracellular Orion’s approach to engineering ligand analogs involves leaving the ‘address’ binding interface on the extracellular

series of evidence shows that TGR5 induces protein kinase B (AKT), nuclear factor kappa-B (NF-κB), extracellular

STAM1 (signal-transducing adaptor molecule) to βarr1 and focal adhesion kinase phosphorylation but not extracellular

Docking analysis of rs35106420, harbored in the ADGLR3-hormone receptor domain (HRM, a common extracellular

β2-adrenergic receptor Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular HCAR2 Antipsychotic displays dual GPCR binding mode GPCRs in Cardiology, Endocrinology, and Taste An extracellular

affected by Wnt ligands, in contrast to other members of the GPCR superfamily for which the binding of extracellular

capable of self-activation via an autoproteolysis process that removes the inhibitory GAIN domain on the extracellular

Instead, a collection of titratable residues spans from the extracellular surface to the transmembrane Specifically, the study revealed that the protonation of key residues surrounding an extracellular facing

protein signaling from endosomes Cellular lipids regulate the conformational ensembles of the disordered intracellular HT 2A -mGlu2 receptor complex in living cells GPCRs in Oncology and Immunology Metabolic crosstalk: Extracellular

differentially regulates G protein signalling Ethan Dintzner, Demet Araç, et al. for their work on The far extracellular fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles The far extracellular

intermolecular interactions of kurarinone with the key residues of the deep orthosteric binding pocket and the extracellular

polarity "The adhesion family of G protein-coupled receptors (GPCRs) is defined by an N-terminal large extracellular

This Nbs binds to the extracellular surface of the Rhodopsin receptor and stabilizes the photo-activated Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular

protein-coupled receptors (GPCRs) are cell surface receptors that mediate the function of a great variety of extracellular

of 7α,25-OHC/GPR183-induced mechano-allodynia was associated with significant activation of MAPKs (extracellular

Axon regeneration in response to injury is determined by the interaction between the extracellular environment

Intracellular calcium ([Ca2+]i) signaling is a critical regulator of chondrogenesis, chondrocyte differentiation modified the temporal dynamics of hM3Dq [Ca2+]i signaling, increased cell proliferation, and enhanced matrix (GPCR)-mediated [Ca2+]i signaling involvement in chondroprogenitor proliferation and cartilage-like matrix