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450 items found for "GPCR Drug Discovery"

  • The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

    < GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

  • GPCR Retreat 2023 - Part II

    GPCR Podcast << Back to podcast list Dr. He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases. GPCR About Victoria Rasmussen "Victoria Rasmussen is a graduate fellow in Dr. She is currently working to understand the signaling and degradation of GPCRs in disease states to help

  • Ep 146 with Dr Michael Feigin

    target discovery. GPCR Targeted Drugs and Gene Regulation in Cancer Cells Mike presented research on the effect of GPCR-targeted lab, which led to the discovery of potential tumor suppressors and oncogenes in melanoma. Scientific Journey and Drug Discovery Challenges Mike shared significant moments in his scientific journey , including the discovery of RGS proteins and its impact on his research approach.

  • Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors

    ) are the most frequently exploited drug target family, moreover they are often found mutated in cancer Our approach was confirmed by re-discovery of established cancer targets such as the LPA and mGlu receptor Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

  • A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis

    < GPCR News < GPCRs in Oncology and Immunology A virally encoded GPCR drives glioblastoma through feed-forward Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Session VI | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program formation, maintenance and degeneration Yimin Zou Antibody-drug conjugates targeting CD97 in glioblastoma Yimin Zou on the web UC San Diego Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis To exploit this expression profile, we have developed antibody-drug conjugates (ADCs) targeting CD97, GPCR < Previous Session Next Session >

  • The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy

    < GPCR News < GPCRs in Oncology and Immunology The power of many: Multilevel targeting of representative GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Ep 109 with Dr. Katarina Nemec

    GPCR Podcast << Back to podcast list Dr. Katarina Nemec About Dr. engaged in researching molecular mechanisms that govern human (patho-)physiology and their interplay with drugs I aim to discover new therapeutic approaches, and druggable molecules or refine canonical drug targets to create drugs with fewer adverse effects. I want to combine experimental approaches with data-driven discovery and adopt data science methodology

  • Ep 29 with Eleonora Comeo

    GPCR Podcast << Back to podcast list Eleonora Comeo About this episode Eleonora Comeo is a doctoral candidate in Medicinal Chemistry and Drug Discovery in the joint program of the University of Nottingham in the We sat down to chat about GPCRs, synthesizing labeled ligands, and her unique position that allows her to work with GPCR scientists on 2 continents. GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand

  • Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway

    < GPCR News < GPCRs in Oncology and Immunology Glucose and HODEs regulate Aspergillus ochraceus quorum News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication

    < GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Interplay between G protein-coupled receptors and nanotechnology

    Although GPCRs are the molecular targets of the majority of marketed drugs, the poor pharmacokinetics to overcome their obstacles, robustly elevating drug efficacy and safety. It will provide a fundamental platform for developing powerful and safe GPCR-targeted drugs and nanoparticle STATEMENT OF SIGNIFICANCE: GPCRs as molecular targets for the majority of marketed drugs are naturally Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience

  • Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

    in the areas of drug discovery and structural biology of membrane proteins. has been involved in studying G protein coupled signal transduction for many years and has made key discoveries She has received numerous awards, including the Glaxo Cardiovascular Discovery Award, the Distinguished GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by

  • Ep 152 with Dr Arthur Christopoulos

    His research focuses on novel paradigms of drug action at GPCRs, particularly allosteric modulation and discovery. his mentors and significant discoveries related to allosteric receptors. discovery. Allosteric Modulation and Drug Discovery Yamina and Arthur delved into the complexities of protein-protein

  • Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers

    < GPCR News < GPCRs in Oncology and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 Hence, we provide an overview containing the discovery history, protein structure, signaling pathways Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology

  • Ep 84 with Rosie Dawaliby

    GPCR Podcast << Back to podcast list Dr. Rosie Dawaliby About Dr. Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially GPCR. In 2016, I joined a company that specialized in therapeutic candidate discovery targeting GPCR ( Confo Therapeutics ) as a team and project leader for antibody discovery for metabolic and inflammatory diseases

  • A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages

    < GPCR News < GPCRs in Oncology and Immunology A disturbed metabolite-GPCR axis is associated with microbial News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach

    < GPCR News < GPCRs in Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10

    < GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression

    Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no drug has yet been approved to stop fibrosis progression. for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs , and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs into GPCR function GPCR Activation and Signaling More from Dr.

  • NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling

    < GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology, Endocrinology, and Taste GPCRs GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Distinct sub-cellular signal propagation as a component of functional selectivity

    to our understanding of this major class of drug targets. energy transfer (BRET) resulted in the development of screening assays that are now widely used for drug discovery. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires 22nd GPCR Retreat Sponsored by

  • Session II | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program a key regulator of lymphatic endothelial cell identity and function Monserrat Avila Zozaya Adhesion GPCR My research focuses on understanding the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic GPCR Adhesion GPCR BAI1/ADGRB1 can block IGF1R-mediated growth signalling, increase radiosensitivity Like many other aGPCRs, ADGRG6 undergoes autoproteolysis at the GPCR-autoproteolysis site (GPS) enclosed

  • G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression

    Finally, we review the progress of clinical trials of GPCR-targeted drugs for cancer treatment, which Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCRs in Cardiology GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Sponsorship Prospectus for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    SPONSORSHIP PROSPECTUS Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Sponsor We are delighted to present the sponsorship opportunities available for Adhesion GPCR Workshop 2024, premier scientific meeting bringing together leaders and innovators in G Protein-Coupled Receptor (GPCR About the Adhesion GPCR Workshop 2024: Adhesion GPCR Workshop 2024 is a high-profile expert conference GPCR workshop 2024 and its preliminary program.

  • Ep 156 with Dr. Justin English

    GPCR Podcast << Back to podcast list Empowering Drug Discovery for the GPCR Community with Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs

  • miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population

    < GPCR News < GPCRs in Oncology and Immunology miR-19a may function as a biomarker of oral squamous cell GPCR News Call for GPCR papers GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

  • Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem

    Register for the AGPCR24 Welcome to the Adhesion GPCR Workshop 2024 , hosted in the vibrant heart of license, etc), as this will be required at the venue entrance Register now to join the exclusive Adhesion GPCR 24, 2024 October 25, 2024 *Flash Presentations: 10 min *Talks 20 min (15 min+ 5 min questions Check AGPCR Yamina Berchiche at the Dr.GPCR Newsletter Learn more about the Adhesion GPCR workshop 2024 Up Abstract

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