GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations.

GPCR Activation and Signaling Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances

Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia

Additionally, using the Gαq/11 inhibitor YM-254890, GPCR kinase 2 and 3 (GRK2 and GRK3) KO cells, and demonstrate that internalization of rat mGlu5a is mediated by Gαq/11 proteins (77% of the response), GRK2 (27%), and AP-2 (29%), but not GRK3.

β-arrestin2: Key players in immune cell functions and inflammation "G protein-coupled receptor kinase type 2 (GRK2 The kinase GRK2 and the multifunctional scaffolding protein β-arrestin2 are key integrated signaling GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological implications of GRK2/β-arrestin2 in various inflammatory diseases."

In VSMC, G protein-coupled receptor kinase 2 (GRK2) is known to regulate numerous vasoconstrictor GPCRs As GRK2 is implicated in controlling various aspects of cellular growth, we examined whether GRK2 could Using two indices of cell growth, we show that PI3K inhibition and depletion of GRK2 expression produced Furthermore, GRK2-knockdown ablated the sustained phase of endothelin-1 and angiotensin-II-stimulated Conversely, the GRK2 inhibitor compound 101 did not affect vasoconstrictor-driven Akt phosphorylation