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88 items found for "Haicang Zhang"
- Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
A much smaller conformational change of helix VI upon activation than previously solved class A GPCR-Gi
- Molecular insights into regulation of constitutive activity by RNA editing 5HT2C serotonin receptor
September 2022 "RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter
- Multifunctional role of GPCR signaling in epithelial tube formation
requires Rho1-dependent actomyosin contractility to generate the cellular forces that drive cell shape changes
- Multifunctional role of GPCR signaling in epithelial tube formation
requires Rho1-dependent actomyosin contractility to generate the cellular forces that drive cell shape changes
- Location bias contributes to functionally selective responses of biased CXCR3 agonists
The signaling profile of CXCR3 changes as it traffics from the plasma membrane to endosomes in a ligand-specific
- Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs
amino group that contributes to receptor binding, and the functioning of GPCRs may involve protonation change
- Decoding β-Arrestins: from Structure to function
Following extracellular stimulus detection, receptor activation initiates conformational changes, exposing fluorescence microscopy assays employ conformation-selective probes for monitoring activation-induced changes not all receptors recruit both isoforms equally and arrestins can undergo different conformational changes Changes in the availability of regulatory proteins like GRKs can impact GPCR phosphorylation and subsequent
- Helix 8 in chemotactic receptors of the complement system
active and inactive C5aR1 receptor conformations has provided insights into details of local and global changes
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
We analyzed the receptor conformational changes and described interactions within its key regions and
- Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System
partial agonist, and biased agonist outcomes in various primary and clonal cell systems, with even small changes
- TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms
TRPM3 expression patterns differ between species and change during development.
- From DNA day to GPCR genomics
Thanks to recent scientific advances, we now have a better understanding of the structural changes that Additionally, there have been recent discoveries of the conformational changes that occur during G-protein
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
trajectories revealed that relative populations of receptors undergoing various modes of diffusion change
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
of reduction in severity of chorea, the cardinal motor feature in Huntington disease, as measured by change
- Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
trajectories revealed that relative populations of receptors undergoing various modes of diffusion change
- 📰 GPCR Weekly News, September 4 to 10, 2023
Magazine's for Pioneering AI-Driven Drug Discovery Domain Therapeutics CEO Pascal Neuville to Discuss Game-Changing Drug Targets: Allosteric Function and Biased Signaling" at the DOT October 3, 2023 | FREE Seminar: Changing
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
expression levels of the two genes were different between male and female adults, and there were significant changes
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
assays to monitor β-arrestin recruitment or signaling, and assays to monitor receptor conformational changes
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
allowed us to construct an exquisitely detailed structure‐activity relationship that identifies small changes
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Keep in mind that you can always change your email preferences in your account settings. GPCRs in Neuroscience Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain
- Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
Here, we show the conformational changes for βarr activation upon the C tail- and TM core-mediated interactions
- Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1
as this was the first description of ACKR1 expression by any leukocyte type and, if correct, would change
- Effect Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells
this study, we investigated the effects of THC and CBD on the differentiation of MECs by assessing changes
- Phospholipid Scrambling by G Protein-Coupled Receptors
Conformational changes that facilitate scrambling are distinct from those associated with GPCR signaling
- Newly launched antibody libraries put hard-to-drug targets within reach
The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
The changes in amyloid pathology are accompanied by robust microglial and astrocytic hypertrophy, which
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen Hsu , Chun-Chun Chang Drugs like Ozempic will change the world GPCR Events, Meetings, and Webinars November 5 - 7, 2024 | 16th
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes