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45 items found for "Howard Rockman"
- Platelets in the NETworks interweaving inflammation and thrombosis
NETs were also detected in thrombotic lesions in several disease backgrounds, pointing towards a role
- Overview of adhesion GPCRs self-activation
where Gi had the fewest hydrophobic and polar interactions with the receptor and the αH5 tilt of G12 towards G-protein coupling, since the change of amino acids in positions close to this position favored signaling toward
- 📰 GPCR Weekly News, August 7 to 13, 2023
neuropeptide receptor npr-38 regulates avoidance and stress-induced sleep in Caenorhabditis elegans Towards
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
when searching for novel receptor ligands, as “ligand-based approaches often bias molecule generation towards Towards a comprehensive understanding of GPCRs, ligands, diseases, and their associations: open-access
- Therapeutic validation of an orphan G protein‐coupled receptor
there is still a lot to be done in respect to tool compounds to study the function of this receptor towards
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Industry News Septerna Bolsters Leadership Team as the Company Advances its Multi-Product Pipeline Toward
- 📰 GPCR Weekly News, July 31 to August 6, 2023
emerging methods for probing neuropeptide transmission Nanowire Biosensors with Olfactory Proteins: Towards
- VAMP2: a crucial player in the delivery of MOR to the synapse
the SNARE complex, including vesicle-associated membrane protein 2 (VAMP2), regulate this last step toward
- Unlocking the Future of Medicine: Advancements in GPCR Research
, GPCRs, and more Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward
- 📰 GPCR Weekly News, February 20 to 26, 2023
modulation of conserved motifs and helices in 5HT2BR: Advances drug discovery and therapeutic approach towards
- GPCR Buzz of the Week | Sep 23 - 29, 2024
Let's set sail towards exciting discoveries and groundbreaking achievements together!
- Chemokine receptor-targeted drug discovery: progress and challenges
Drug discovery is shifting towards the development of biased ligands, which promote the engagement of
- 📰 GPCR Weekly News, January 30 to February 5, 2023
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards
- Odorant receptors – a bit of smell for drug discovery
The development of antibodies directed towards an OR could either drive receptor inactivation or activation
- Adhesion GPCR Consortium Newsletter - May 2024
A small step toward leveling the playing field.
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
Towards a molecular understanding of endosomal trafficking by Retromer and Retriever.
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
Orion’s discovery process is that the initial search for potent target receptor modulators is agnostic towards Orion CCL5 superagonist analog significantly increased both the potency and selectivity of the payload towards